Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell death
RL Ang, M Chan, D Legarda… - Proceedings of the …, 2021 - National Acad Sciences
SHARPIN, together with RNF31/HOIP and RBCK1/HOIL1, form the linear ubiquitin chain
assembly complex (LUBAC) E3 ligase that catalyzes M1-linked polyubiquitination. Mutations …
assembly complex (LUBAC) E3 ligase that catalyzes M1-linked polyubiquitination. Mutations …
Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency
H Oda, K Manthiram, PP Chavan, E Rieser, Ö Veli… - Nature …, 2024 - nature.com
The linear ubiquitin assembly complex (LUBAC) consists of HOIP, HOIL-1 and SHARPIN
and is essential for proper immune responses. Individuals with HOIP and HOIL-1 …
and is essential for proper immune responses. Individuals with HOIP and HOIL-1 …
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
SHARPIN is a ubiquitin-binding and ubiquitin-like-domain-containing protein which, when
mutated in mice, results in immune system disorders and multi-organ inflammation,. Here we …
mutated in mice, results in immune system disorders and multi-organ inflammation,. Here we …
Innate immune adaptor MyD88 deficiency prevents skin inflammation in SHARPIN-deficient mice
Mice deficient in SHANK-associated RH domain-interacting protein (SHARPIN), a
component of the linear ubiquitin chain assembly complex (LUBAC), develop a …
component of the linear ubiquitin chain assembly complex (LUBAC), develop a …
Differential involvement of the Npl4 zinc finger domains of SHARPIN and HOIL-1L in linear ubiquitin chain assembly complex-mediated cell death protection
S Shimizu, H Fujita, Y Sasaki, T Tsuruyama… - … and cellular biology, 2016 - Taylor & Francis
The linear ubiquitin chain assembly complex (LUBAC) participates in NF-κB activation and
cell death protection. Loss of any of the three LUBAC subunits (catalytic HOIP, accessory …
cell death protection. Loss of any of the three LUBAC subunits (catalytic HOIP, accessory …
Roles of linear ubiquitinylation, a crucial regulator of NF‐κB and cell death, in the immune system
K Sasaki, K Iwai - Immunological reviews, 2015 - Wiley Online Library
Linear ubiquitinylation, a newly identified post‐translational modification, is catalyzed by the
linear ubiquitin assembly complex (LUBAC), which is composed of three different subunits …
linear ubiquitin assembly complex (LUBAC), which is composed of three different subunits …
Cross-regulation between LUBAC and caspase-1 modulates cell death and inflammation
The linear ubiquitin assembly complex (LUBAC) is an essential component of the innate and
adaptive immune system. Modification of cellular substrates with linear polyubiquitin chains …
adaptive immune system. Modification of cellular substrates with linear polyubiquitin chains …
SHARPIN controls the development of regulatory T cells
V Redecke, V Chaturvedi, J Kuriakose, H Häcker - Immunology, 2016 - Wiley Online Library
SHARPIN is an essential component of the linear ubiquitin chain assembly complex
(LUBAC) complex that controls signalling pathways of various receptors, including the …
(LUBAC) complex that controls signalling pathways of various receptors, including the …
Distinct role of IL-1β in instigating disease in Sharpincpdm mice
Mice deficient in SHARPIN (Sharpin cpdm mice), a member of linear ubiquitin chain
assembly complex (LUBAC), develop severe dermatitis associated with systemic …
assembly complex (LUBAC), develop severe dermatitis associated with systemic …
TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice
SHARPIN regulates immune signaling and contributes to full transcriptional activity and
prevention of cell death in response to TNF in vitro. The inactivating mouse Sharpin cpdm …
prevention of cell death in response to TNF in vitro. The inactivating mouse Sharpin cpdm …