Studies on the mode of action of the antifungal hexapeptide PAF26
A Munoz, B López-García… - Antimicrobial Agents and …, 2006 - Am Soc Microbiol
The small antimicrobial peptide PAF26 (Ac-RKKWFW-NH2) has been identified by a
combinatorial approach and shows preferential activity toward filamentous fungi. In this …
combinatorial approach and shows preferential activity toward filamentous fungi. In this …
Understanding the mechanism of action of cell-penetrating antifungal peptides using the rationally designed hexapeptide PAF26 as a model
A Muñoz, M Gandía, E Harries, L Carmona… - Fungal Biology …, 2013 - Elsevier
Antimicrobial peptides (AMPs) are being actively explored as novel pharmaceuticals, plant
protection agents or food preservatives. A decade ago, the cationic peptide PAF26 was …
protection agents or food preservatives. A decade ago, the cationic peptide PAF26 was …
Two functional motifs define the interaction, internalization and toxicity of the cell-penetrating antifungal peptide PAF26 on fungal cells
A Munoz, E Harries, A Contreras-Valenzuela… - PLoS …, 2013 - journals.plos.org
The synthetic, cell penetrating hexapeptide PAF26 (RKKWFW) is antifungal at low
micromolar concentrations and has been proposed as a model for cationic, cell-penetrating …
micromolar concentrations and has been proposed as a model for cationic, cell-penetrating …
Concentration‐dependent mechanisms of cell penetration and killing by the de novo designed antifungal hexapeptide PAF26
Recent evidence indicates that antimicrobial peptides can kill microbes in more complex
ways than just by membrane permeabilization. In this study, the mechanism of …
ways than just by membrane permeabilization. In this study, the mechanism of …
Concatemerization increases the inhibitory activity of short, cell-penetrating, cationic and tryptophan-rich antifungal peptides
B López-García, E Harries, L Carmona… - Applied microbiology …, 2015 - Springer
There are short cationic and tryptophan-rich antifungal peptides such as the hexapeptide
PAF26 (RKKWFW) that have selective toxicity and cell penetration properties against fungal …
PAF26 (RKKWFW) that have selective toxicity and cell penetration properties against fungal …
Antimicrobial properties of derivatives of the cationic tryptophan-rich hexapeptide PAF26
A Muñoz, B López-García, E Pérez-Payá… - Biochemical and …, 2007 - Elsevier
Short antimicrobial peptides represent an alternative to fight pathogen infections. PAF26 is a
hexapeptide identified previously by a combinatorial approach against the fungus …
hexapeptide identified previously by a combinatorial approach against the fungus …
Parallel evaluation of antimicrobial peptides derived from the synthetic PAF26 and the human LL37
B López-García, W Ubhayasekera, RL Gallo… - Biochemical and …, 2007 - Elsevier
The antimicrobial hexapeptide PAF26 was de novo designed towards phytopathogenic
fungi of agricultural importance. To analyze its clinical potential, the activity of PAF26 has …
fungi of agricultural importance. To analyze its clinical potential, the activity of PAF26 has …
Identification of novel hexapeptides bioactive against phytopathogenic fungi through screening of a synthetic peptide combinatorial library
B López-García, E Pérez-Payá… - Applied and …, 2002 - Am Soc Microbiol
The purpose of the present study was to improve the antifungal activity against selected
phytopathogenic fungi of the previously identified hexapeptide PAF19. We describe some …
phytopathogenic fungi of the previously identified hexapeptide PAF19. We describe some …
Design of novel peptide analogs with potent fungicidal activity, based on PMAP-23 antimicrobial peptide isolated from porcine myeloid
DG Lee, PI Kim, Y Park, ER Woo, JS Choi… - Biochemical and …, 2002 - Elsevier
PMAP-23 is a 23-mer peptide derived from porcine myeloid. To develop novel antifungal
peptides useful as therapeutic drugs, it would require a strong fungicidal activity against …
peptides useful as therapeutic drugs, it would require a strong fungicidal activity against …
Mapping and Identification of Antifungal Peptides in the Putative Antifungal Protein AfpB from the Filamentous Fungus Penicillium digitatum
S Garrigues, M Gandía, A Borics, F Marx… - Frontiers in …, 2017 - frontiersin.org
Antifungal proteins (AFPs) from Ascomycetes are small cysteine-rich proteins that are
abundantly secreted and show antifungal activity against non-producer fungi. A gene coding …
abundantly secreted and show antifungal activity against non-producer fungi. A gene coding …
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