Studies on the mode of action of the antifungal hexapeptide PAF26

A Munoz, B López-García… - Antimicrobial Agents and …, 2006 - Am Soc Microbiol
The small antimicrobial peptide PAF26 (Ac-RKKWFW-NH2) has been identified by a
combinatorial approach and shows preferential activity toward filamentous fungi. In this …

Understanding the mechanism of action of cell-penetrating antifungal peptides using the rationally designed hexapeptide PAF26 as a model

A Muñoz, M Gandía, E Harries, L Carmona… - Fungal Biology …, 2013 - Elsevier
Antimicrobial peptides (AMPs) are being actively explored as novel pharmaceuticals, plant
protection agents or food preservatives. A decade ago, the cationic peptide PAF26 was …

Two functional motifs define the interaction, internalization and toxicity of the cell-penetrating antifungal peptide PAF26 on fungal cells

A Munoz, E Harries, A Contreras-Valenzuela… - PLoS …, 2013 - journals.plos.org
The synthetic, cell penetrating hexapeptide PAF26 (RKKWFW) is antifungal at low
micromolar concentrations and has been proposed as a model for cationic, cell-penetrating …

Concentration‐dependent mechanisms of cell penetration and killing by the de novo designed antifungal hexapeptide PAF26

A Muñoz, JF Marcos, ND Read - Molecular Microbiology, 2012 - Wiley Online Library
Recent evidence indicates that antimicrobial peptides can kill microbes in more complex
ways than just by membrane permeabilization. In this study, the mechanism of …

Concatemerization increases the inhibitory activity of short, cell-penetrating, cationic and tryptophan-rich antifungal peptides

B López-García, E Harries, L Carmona… - Applied microbiology …, 2015 - Springer
There are short cationic and tryptophan-rich antifungal peptides such as the hexapeptide
PAF26 (RKKWFW) that have selective toxicity and cell penetration properties against fungal …

Antimicrobial properties of derivatives of the cationic tryptophan-rich hexapeptide PAF26

A Muñoz, B López-García, E Pérez-Payá… - Biochemical and …, 2007 - Elsevier
Short antimicrobial peptides represent an alternative to fight pathogen infections. PAF26 is a
hexapeptide identified previously by a combinatorial approach against the fungus …

Parallel evaluation of antimicrobial peptides derived from the synthetic PAF26 and the human LL37

B López-García, W Ubhayasekera, RL Gallo… - Biochemical and …, 2007 - Elsevier
The antimicrobial hexapeptide PAF26 was de novo designed towards phytopathogenic
fungi of agricultural importance. To analyze its clinical potential, the activity of PAF26 has …

Identification of novel hexapeptides bioactive against phytopathogenic fungi through screening of a synthetic peptide combinatorial library

B López-García, E Pérez-Payá… - Applied and …, 2002 - Am Soc Microbiol
The purpose of the present study was to improve the antifungal activity against selected
phytopathogenic fungi of the previously identified hexapeptide PAF19. We describe some …

Design of novel peptide analogs with potent fungicidal activity, based on PMAP-23 antimicrobial peptide isolated from porcine myeloid

DG Lee, PI Kim, Y Park, ER Woo, JS Choi… - Biochemical and …, 2002 - Elsevier
PMAP-23 is a 23-mer peptide derived from porcine myeloid. To develop novel antifungal
peptides useful as therapeutic drugs, it would require a strong fungicidal activity against …

Mapping and Identification of Antifungal Peptides in the Putative Antifungal Protein AfpB from the Filamentous Fungus Penicillium digitatum

S Garrigues, M Gandía, A Borics, F Marx… - Frontiers in …, 2017 - frontiersin.org
Antifungal proteins (AFPs) from Ascomycetes are small cysteine-rich proteins that are
abundantly secreted and show antifungal activity against non-producer fungi. A gene coding …