Objectives: We examined the effect of mechanical unloading with ventricular assist device
(VAD) therapy on myocardial inducible nitric oxide synthase (iNOS) expression and …

In this issue of the Journal, Patten et al.(1) report the impact of unloading therapy in humans
with advanced stage D heart failure who were supported with a left ventricular-assist device …

BACKGROUND:: Apoptosis contributes to ventricular remodeling in heart failure (HF). Nitric
oxide (NO) inhibits caspase 3, a key effector apoptotic enzyme. We hypothesized that …

Background: Increased expression of inducible nitric oxide synthase (iNOS) has been
described in humans with cardiomyopathies. Most animal models of ischemia-induced heart …

OBJECTIVES The objective of the study was to evaluate nitric oxide (NO) mediated
regulation of mitochondrial respiration after implantation of a mechanical assist device in …

Background Molecular mechanisms underlying the deterioration of patients undergoing LV
assist device (LVAD) implantation remain poorly understood. We studied the cytokines …

Background—An increasing number of observations in patients with end-stage heart failure
suggest that chronic ventricular unloading by mechanical circulatory support may lead to …

Background. Mechanical unloading with a left ventricular assist device (LVAD) can improve
clinical indices of heart failure and alter myocardial tumor necrosis factor–α (TNFα) …

Objectives. The study was designed to evaluate the functional impact of nitric oxide (NO)
generation within the myocardium on cardiac contraction in the failing human heart …

Inducible nitric oxide synthase (iNOS) has been implicated in the pathophysiology of
congestive heart failure (CHF). Given the extensive evidence supporting this concept, we …