In Parkinson's disease (PD) chronic inflammation occurs in the substantia nigra (SNc)
concurrently with dopaminergic neurodegeneration. In models of PD, microglial activation …

Background The aim of this study was to examine the effect of AAV2-hIL-10 (vector
containing cDNA for human interleukin 10) on dopaminergic system activity (measured as …

Neuroinflammation has been involved in pathogenesis of Parkinson's disease (PD), a
chronic neurodegenerative disease characterized neuropathologically by progressive …

Brain inflammation is a double-edged sword. It is required for brain repair in acute damage,
whereas chronic inflammation and autoimmune disorders are neuropathogenic. Certain …

The role of anti-inflammatory cytokines in Parkinson's disease is not completely understood.
In this study, using mesencephalic neuron-glia cultures, we report that both pretreatment …

Inflammation has been increasingly recognized to play an important role in the
pathogenesis of Parkinson's disease (PD). Using immunocytochemistry and electron …

Abstract Background The etiology of Parkinson's disease (PD) remains elusive despite
identification of several genetic mutations. It is more likely that multiple factors converge to …

Cerebral dopamine neurotrophic factor (CDNF) protein has been shown to protect the
nigrostriatal dopaminergic pathway when given as intrastriatal infusions in rat and mouse …

Neuroinflammatory processes have been implicated in the progressive loss of ventral
midbrain dopaminergic (DA) neurons that give rise to Parkinson's disease (PD), a late-onset …

Accumulating evidence suggests that microglia and peripheral immune cells may play
determinant roles in the pathogenesis of Parkinson's disease (PD). Consequently, there is a …