Cerebral ischemia has a harmful effect on the synapse associated with neurological
impairment. The “tripartite synapse” is assembled by the pre-and postsynaptic terminals …

Synaptic repair in the ischemic brain is a complex process that requires reorganization of the
actin cytoskeleton. Ezrin, radixin, and moesin (ERM) are a group of evolutionarily conserved …

Urokinase-type plasminogen activator (uPA) is a serine proteinase that, upon binding to its
receptor (uPAR), catalyzes the conversion of plasminogen into plasmin on the cell surface …

The last two decades have witnessed a rapid decrease in mortality due to acute cerebral
ischemia that paradoxically has led to a rapid increase in the number of patients that survive …

Urokinase-type plasminogen activator (uPA) is a serine proteinase that upon binding to its
receptor (uPAR) catalyzes the conversion of plasminogen into plasmin on the cell surface …

Spines are dendritic protrusions that receive most of the excitatory input in the brain. Early
after the onset of cerebral ischemia dendritic spines in the peri-infarct cortex are replaced by …

The plasminogen activation (PA) system was originally thought to exclusively promote the
degradation of fibrin by catalyzing the conversion of plasminogen into plasmin via two serine …

The repair of injured tissue is a highly complex process that involves cell proliferation,
differentiation, and migration. Cell migration requires the dismantling of intercellular contacts …

The central nervous system has a very high energy requirement. Accordingly, despite
representing only 2% of the body's mass, the brain uses 20% of the total oxygen …

Despite the fact that ischemic stroke has been considered a leading cause of mortality in the
world, recent advances in our understanding of the pathophysiological mechanisms …