Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease
DJ Verlaan, S Berlivet, GM Hunninghake… - The American Journal of …, 2009 - cell.com
Common SNPs in the chromosome 17q12-q21 region alter the risk for asthma, type 1
diabetes, primary biliary cirrhosis, and Crohn disease. Previous reports by us and others …
diabetes, primary biliary cirrhosis, and Crohn disease. Previous reports by us and others …
Chromosome 17q21 genes ORMDL3 and GSDMB in asthma and immune diseases
Chromosome 17q21 contains a cluster of genes including ORMDL3 and GSDMB, which
have been highly linked to asthma in genome-wide association studies. ORMDL3 is …
have been highly linked to asthma in genome-wide association studies. ORMDL3 is …
17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells
BJ Schmiedel, G Seumois… - Nature …, 2016 - nature.com
Asthma and autoimmune disease susceptibility has been strongly linked to genetic variants
in the 17q21 haploblock that alter the expression of ORMDL3; however, the molecular …
in the 17q21 haploblock that alter the expression of ORMDL3; however, the molecular …
A large-scale, consortium-based genomewide association study of asthma
MF Moffatt, IG Gut, F Demenais… - … England Journal of …, 2010 - Mass Medical Soc
Background Susceptibility to asthma is influenced by genes and environment; implicated
genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful …
genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful …
Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus
Single-nucleotide polymorphisms (SNPs) in GSDMB (Gasdermin B) and ORMDL3 (ORMDL
sphingolipid biosynthesis regulator 3) are strongly associated with childhood asthma, but …
sphingolipid biosynthesis regulator 3) are strongly associated with childhood asthma, but …
ORMDL3 Gene Is Associated with Asthma in Three Ethnically Diverse Populations
J Galanter, S Choudhry, C Eng, S Nazario… - American journal of …, 2008 - atsjournals.org
Rationale: Independent replication of genetic associations in complex diseases, particularly
in whole-genome association studies, is critical to confirm the association. Objectives: A …
in whole-genome association studies, is critical to confirm the association. Objectives: A …
The association of GSDMB and ORMDL3 gene polymorphisms with asthma: a meta-analysis
CN Zhao, Y Fan, JJ Huang, HX Zhang… - Allergy, asthma & …, 2015 - synapse.koreamed.org
Purpose ORM1-like 3 (ORMDL3) belongs to a highly conserved protein family which is
anchored as transmembrane protein in the endoplasmic reticulum. Gasdermin B (GSDMB) …
anchored as transmembrane protein in the endoplasmic reticulum. Gasdermin B (GSDMB) …
Unifying candidate gene and GWAS Approaches in Asthma
S Michel, L Liang, M Depner, N Klopp, A Ruether… - PloS one, 2010 - journals.plos.org
The first genome wide association study (GWAS) for childhood asthma identified a novel
major susceptibility locus on chromosome 17q21 harboring the ORMDL3 gene, but the role …
major susceptibility locus on chromosome 17q21 harboring the ORMDL3 gene, but the role …
A sequence variant on 17q21 is associated with age at onset and severity of asthma
E Halapi, DF Gudbjartsson, GM Jonsdottir… - European journal of …, 2010 - nature.com
A sequence variant (rs7216389-T) near the ORMDL3 gene on chromosome 17q21 was
recently found to be associated with childhood asthma. We sought to evaluate the effect of …
recently found to be associated with childhood asthma. We sought to evaluate the effect of …
Genetic architecture of transcript-level variation in humans
We report here the results of testing the pairwise association of 12,747 transcriptional gene-
expression values with more than two million single-nucleotide polymorphisms (SNPs) in …
expression values with more than two million single-nucleotide polymorphisms (SNPs) in …