Mutations in the Nkx2-5 gene are a main cause of congenital heart disease. Several studies
have addressed the phenotypic consequences of disrupting the Nkx2-5 gene locus …

Background—The transcription factor NKX2-5 is crucial for heart development, and
mutations in this gene have been implicated in diverse congenital heart diseases and …

Background Mutation of NKX2-5 could lead to the development of congenital heart disease
(CHD) which is a common inherited disease. This study aimed to investigate the …

Nkx2-5 is one of the master regulators of cardiac development, homeostasis and disease.
This transcription factor has been previously associated with a suite of cardiac congenital …

Human mutations in Nkx2-5 lead to progressive cardiomyopathy and conduction defects via
unknown mechanisms. To define these pathways, we generated mice with a ventricular …

Congenital heart defects (CHDs) represent the biggest fraction of morbid congenital
anomalies worldwide. Owing to their complex inheritance patterns and multifactorial …

Congenital heart disease (CHD) is the most common form of birth defect and is the most
prevalent non-infectious cause of infant death. A growing body of evidence documents that …

Cell type-specific expression of the developmental gene is conferred by distinct enhancer
elements. Current knowledge about mechanisms in Nkx2-5 transcriptional regulation and its …

The Nkx2-5 gene codes for a transcription factor that plays a critical role in heart
development. Heterozygous mutations in NKX2-5 in both human and mice result in …

Multiple animal studies have demonstrated the important role of NKX2. 5, a homeobox
transcription factor, in cardiogenesis [Komuro and Izumo, 1993; Lyons et al., 1995; Grow and …