In higher eukaryotes, histone methylation is involved in maintaining cellular identity during
somatic development. As most nucleosomes are replaced by protamines during …

Because nucleosomes are widely replaced by protamine in mature human sperm, the
epigenetic contributions of sperm chromatin to embryo development have been considered …

Spermatogenesis is a highly complex cell differentiation process that is governed by unique
transcriptional regulation and massive chromatin alterations, which are required for meiosis …

Histone modifications are central to the regulation of all DNA-dependent processes. Lys64
of histone H3 (H3K64) lies within the globular domain at a structurally important position. We …

Histone modifications influence the interactions of transcriptional regulators with chromatin.
Studies in embryos and embryonic stem (ES) cells have uncovered histone modification …

Repressive H3K27me3 and active H3K4me2/3 together form bivalent chromatin domains,
molecular hallmarks of developmental potential. In the male germline, these domains are …

INTRODUCTION Despite the father transmitting half of the heritable information to the
embryo, the focus of preconception health has been the mother. Paternal effects have been …

Epigenetic modifications of histones regulate gene expression and chromatin structure,.
Here we show that Meisetz (meiosis-induced factor containing a PR/SET domain and zinc …

On fertilisation, gametes undergo epigenetic reorganisation and re-establish totipotency.
Here, we investigate links between chromatin remodelling and asymmetric maintenance of …

Epigenetic modifications, and methylation of histones in particular, dynamically change
during spermatogenesis. Among various methylations of histone H3, methylation of histone …