Mass spectrometry imaging in drug development
Drug discovery and development is a high-risk, expensive endeavor and it commonly takes
about 10− 15 years to obtain marketing approval from project inception. 1 Research efforts …
about 10− 15 years to obtain marketing approval from project inception. 1 Research efforts …
Imaging mass spectrometry: fundamentals and applications to drug discovery
Imaging mass spectrometry (IMS) encompasses a variety of techniques that enable the
chemical imaging of analytes, which range in size from atoms and small molecules to intact …
chemical imaging of analytes, which range in size from atoms and small molecules to intact …
A critical and concise review of mass spectrometry applied to imaging in drug discovery
RJA Goodwin, Z Takats… - … : Advancing the Science of …, 2020 - journals.sagepub.com
During the past decade, mass spectrometry imaging (MSI) has become a robust and
versatile methodology to support modern pharmaceutical research and development. The …
versatile methodology to support modern pharmaceutical research and development. The …
Mass spectrometry imaging for drug distribution studies
B Prideaux, M Stoeckli - Journal of proteomics, 2012 - Elsevier
Since its introduction mass spectrometry imaging (MSI) has proven to be a powerful tool for
the localization of molecules in biological tissues. In drug discovery and development …
the localization of molecules in biological tissues. In drug discovery and development …
Mass spectrometry imaging and its application in pharmaceutical research and development: A concise review
JG Swales, G Hamm, MR Clench… - International Journal of …, 2019 - Elsevier
Understanding the biodistribution, metabolism and accumulation of drugs in the body is a
fundamental of pharmaceutical research and development. Mass Spectrometry imaging …
fundamental of pharmaceutical research and development. Mass Spectrometry imaging …
Current state and future challenges of mass spectrometry imaging for clinical research
RD Addie, B Balluff, JVMG Bovée, H Morreau… - 2015 - ACS Publications
The ability of mass spectrometry imaging (MSI) to localize panels of biomolecules in tissues,
without prior knowledge of their presence and in a label-free manner, has led to a rapid and …
without prior knowledge of their presence and in a label-free manner, has led to a rapid and …
Future technology insight: mass spectrometry imaging as a tool in drug research and development
In pharmaceutical research, understanding the biodistribution, accumulation and
metabolism of drugs in tissue plays a key role during drug discovery and development. In …
metabolism of drugs in tissue plays a key role during drug discovery and development. In …
Mass spectrometry imaging for drugs and metabolites
Mass spectrometric imaging (MSI) is a powerful analytical technique that provides two-and
three-dimensional spatial maps of multiple compounds in a single experiment. This …
three-dimensional spatial maps of multiple compounds in a single experiment. This …
Qualitative and quantitative mass spectrometry imaging of drugs and metabolites
CB Lietz, E Gemperline, L Li - Advanced drug delivery reviews, 2013 - Elsevier
Mass spectrometric imaging (MSI) has rapidly increased its presence in the pharmaceutical
sciences. While quantitative whole-body autoradiography and microautoradiography are the …
sciences. While quantitative whole-body autoradiography and microautoradiography are the …
[HTML][HTML] Quantitative mass spectrometry imaging of drugs and metabolites: a multiplatform comparison
L Lamont, D Hadavi, B Viehmann, B Flinders… - Analytical and …, 2021 - Springer
Mass spectrometry imaging (MSI) provides insight into the molecular distribution of a broad
range of compounds and, therefore, is frequently applied in the pharmaceutical industry …
range of compounds and, therefore, is frequently applied in the pharmaceutical industry …