Activity of several ion channels is controlled by heterotrimeric GTP-binding proteins (G
proteins) via a membrane-delimited pathway that does not involve cytoplasmic …

Several ion channels can be regulated by G proteins in a “membrane-delimited” manner.
The cardiac muscarinic K+ (KACh) channel, which is responsible for the acetylcholine (ACh) …

Injection of rat atrial RNA into Xenopus oocytes resulted in the expression of guanine
nucleotide binding (G) protein-activated K+ channel. Current through the channel could be …

The cardiac G protein-gated K+ channel, I KACh, is activated by application of purified and
recombinant β and γ subunits (Gβγ) of heterotrimeric G proteins to excised inside-out …

Guanine nucleotide binding (G) proteins couple a variety of receptors to ionic channels. Until
recently the pathway was thought to be indirect via cytoplasmic second messengers; now …

Guanine nucleotide binding (G) proteins are heterotrimers that couple a wide range of
receptors to ionic channels. The coupling may be indirect, via cytoplasmic agents, or direct …

Upon stimulation of vagal nerves, acetylcholine (ACh) c is released from axonal terminals
and decelerates the heart beat. This historic discovery by Otto Loewi in the 1920s …

In many tissues, inwardly rectifying K channels are coupled to seven-helix receptors via the
Gi/Go family of heterotrimeric G proteins. This activation proceeds at least partially via G beta …

The activated heterotrimeric guanine nucleotide binding (G) protein Gk, at subpicomolar
concentrations, mimics muscarinic stimulation of a specific atrial potassium current …

Guanine nucleotide-binding proteins (G proteins) activate K+ conductances in cardiac atrial
cells to slow heart rate and in neurons to decrease excitability. cDNAs encoding three …