IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
KL Jønsson, A Laustsen, C Krapp, KA Skipper… - Nature …, 2017 - nature.com
Innate immune activation by macrophages is an essential part of host defence against
infection. Cytosolic recognition of microbial DNA in macrophages leads to induction of …
infection. Cytosolic recognition of microbial DNA in macrophages leads to induction of …
IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes
JF Almine, CAJ O'Hare, G Dunphy, IR Haga… - Nature …, 2017 - nature.com
Many human cells can sense the presence of exogenous DNA during infection though the
cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the second …
cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the second …
[HTML][HTML] A noncanonical function of cGAMP in inflammasome priming and activation
KV Swanson, RD Junkins, CJ Kurkjian… - Journal of Experimental …, 2017 - rupress.org
Recognition of pathogen-associated molecular patterns and danger-associated molecular
patterns by host cells is an important step in innate immune activation. The DNA sensor …
patterns by host cells is an important step in innate immune activation. The DNA sensor …
Cutting edge: USP27X deubiquitinates and stabilizes the DNA sensor cGAS to regulate cytosolic DNA–mediated signaling
Y Guo, F Jiang, L Kong, B Li, Y Yang… - The Journal of …, 2019 - journals.aai.org
Abstract Cyclic GMP-AMP synthase (cGAS), a cytosolic DNA sensor, catalyzes the formation
of the second messenger 2′ 3′-cGAMP that binds to STING and triggers the type I IFN …
of the second messenger 2′ 3′-cGAMP that binds to STING and triggers the type I IFN …
Transcription-independent regulation of STING activation and innate immune responses by IRF8 in monocytes
WW Luo, Z Tong, P Cao, FB Wang, Y Liu… - Nature …, 2022 - nature.com
Sensing of cytosolic DNA of microbial or cellular/mitochondrial origin by cGAS initiates
innate immune responses via the adaptor protein STING. It remains unresolved how the …
innate immune responses via the adaptor protein STING. It remains unresolved how the …
Positive feedback regulation of type I IFN production by the IFN-inducible DNA sensor cGAS
Rapid and robust induction of type I IFN (IFN-I) is a critical event in host antiviral innate
immune response. It has been well demonstrated that cyclic GMP-AMP (cGAMP) synthase …
immune response. It has been well demonstrated that cyclic GMP-AMP (cGAMP) synthase …
STING agonism turns human T cells into interferon‐producing cells but impedes their functionality
Abstract The cGAS‐STING (cyclic GMP‐AMP synthase‐stimulator of interferon genes) axis is
the predominant DNA sensing system in cells of the innate immune system. However …
the predominant DNA sensing system in cells of the innate immune system. However …
cGAS is activated by DNA in a length‐dependent manner
S Luecke, A Holleufer, MH Christensen, KL Jønsson… - EMBO …, 2017 - embopress.org
Cytosolic DNA stimulates innate immune responses, including type I interferons (IFN), which
have antiviral and immunomodulatory activities. Cyclic GMP‐AMP synthase (cGAS) …
have antiviral and immunomodulatory activities. Cyclic GMP‐AMP synthase (cGAS) …
Nonspecific DNA binding of cGAS N terminus promotes cGAS activation
The cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) mediates innate immune
responses against invading pathogens, or against self-dsDNA, which causes autoimmune …
responses against invading pathogens, or against self-dsDNA, which causes autoimmune …