We have previously shown that porcine endothelin (ET-1) releases endothelium-derived
relaxing factor (EDRF) in the rat isolated perfused mesentery. Here we show that both ET-1 …

BACKGROUND The endothelium possesses the ability to modulate vascular tone by the
release of vasodilators and vasoconstrictors, among them endothelium-derived relaxing …

Endothelin-1 is a 21-amino acid endothelial vasoconstrictor peptide that may be the
physiological antagonist of endothelium-derived relaxing factor (EDRF). Endothelin-1 (10 …

Endothelin is a potent vasoconstrictor, whereas endothelium-derived relaxing factor (EDRF)
is a potent vasodilator. Both are produced by the endothelium. Although they have been …

Summary Endothelin-1 (ET-1) is a more potent constrictor of femoral venous than femoral
arterial smooth muscle. By contrast, endothelium-dependent contractions to anoxia are more …

In comparison with snake venom sarafotoxins S6, the novel, 21-amino acid peptide,
endothelin may have selective coronary artery vasoconstrictor actions. We examined …

In vascular beds, a potent vasoconstrictor of endothelin-I (ET-I) is produced by endothelial
cells and released preferentially to the basal side of endothelial cells. It acts on endothelial …

The vascular effects of endothelin-1 (ET) in humans were investigated by brachial artery
infusions of ET into 25 healthy volunteers. Forearm blood flow increased from a mean+/-SD …

The effects of endothelin-1 (ET-1) on tension and membrane potential in rat isolated
mesenteric resistance vessels (MRVs) and on 45 Ca influx, 45 Ca efflux, inositol-1, 4, 5 …

Cultured endothelial cells from bovine thoracic aortas conditioned with serum-free culture
media released an endothelin-1 (ET)-1-like substance. Concentrations of ET-1-like material …