Background Recent research suggests that cerebrovascular endothelial dysfunction during
advanced aging, together with other risk factors, may trigger the neurodegenerative …

Aging and the presence of cerebrovascular disease are associated with increased
incidence of Alzheimer's disease. A common feature of aging and cerebrovascular disease …

Background L-arginine is a semi-essential amino acid with a number of bioactive
metabolites, and altered arginine metabolism has been implicated in the pathogenesis of …

Nitric oxide (NO) produced by endothelial NO synthase (eNOS) is a key regulator of cerebral
blood flow (CBF) dynamics. Mice with eNOS deficiency (eNOS−/-) display age-related …

Increasing evidence implicates endothelial dysfunction in the pathogenesis of Alzheimer's
disease (AD). Nitric oxide (NO) derived from endothelial NO synthase (eNOS) is essential in …

Abstract Vascular Dementia (VaD) accounts for nearly 20% of all cases of dementia. eNOS
plays an important role in neurovascular remodeling, anti-inflammation, and cognitive …

Aging and other cardiovascular risk factors are associated with increased incidence of
Alzheimer's disease (AD). A common feature of cardiovascular risk factors is decreased …

eNOS (endothelial nitric oxide synthase) is critically important enzyme responsible for
regulation of cardiovascular homeostasis. Under physiological conditions, constitutive eNOS …

Both the endothelial (eNOS) and the neuronal (nNOS) isoforms of constitutive Nitric Oxide
Synthase have been implicated in vascular dysfunctions in Alzheimer's disease (AD). We …

Endothelial nitric oxide (NO) is generated by constitutively active endothelial nitric oxide
synthase (eNOS), an essential enzyme responsible for cardiovascular homeostasis …