Chondrogenesis is a multistep process, in which cartilage progenitor cells generate a tissue
with distinct structural and functional properties. Although several approaches to cartilage …

Background During vertebrate embryogenesis the initial stages of bone formation by
endochondral ossification involve the aggregation and proliferation of mesenchymal cells …

To address large gaps in our understanding of the molecular regulation of articular and
growth plate cartilage development in humans, we used our directed differentiation …

Cellular differentiation comprises a progressive, multistep program that drives cells to
fabricate a tissue with specific and site distinctive structural and functional properties …

Articular cartilage is recalcitrant to repair and regeneration. Tissue engineering and
regenerative medicine are potential strategies to treat the damage to articular cartilage. A …

Mesenchymal stem cells (MSCs) are a promising cell source for cartilage tissue engineering
given their chondrogenic potential. This potential has yet to be fully realized, as the …

Tissue-specific gene expression defines cellular identity and function, but knowledge of
early human development is limited, hampering application of cell-based therapies. Here we …

Articular cartilage has only very limited regenerative capacities in humans. Tissue
engineering techniques for cartilage damage repair are limited in the production of hyaline …

Background Cartilage plays a fundamental role in the development of the human skeleton.
Early in embryogenesis, mesenchymal cells condense and differentiate into chondrocytes to …

Human embryonic stem cells (ESCs) offer a promising therapeutic approach for
osteoarthritis (OA). The unlimited source of cells capable of differentiating to chondrocytes …