Cerebral blood flow (CBF) and its distribution are highly sensitive to changes in the partial
pressure of arterial CO2 (PaCO2). This physiological response, termed cerebrovascular …

Cerebrovascular reactivity to changes in the partial pressure of arterial carbon dioxide (P)
via limiting changes in brain [H+] modulates ventilatory control. It remains unclear, however …

Recent advances have clarified how the brain detects CO 2 to regulate breathing (central
respiratory chemoreception). These mechanisms are reviewed and their significance is …

This study examined cerebrovascular reactivity and ventilation during step changes in CO2
in humans. We hypothesized that:(1) end‐tidal P (P) would overestimate arterial P (P) during …

An important determinant of [H+] in the environment of the central chemoreceptors is
cerebral blood flow. Accordingly we hypothesized that a reduction of brain perfusion or a …

In this review, we examine why blood pressure (BP) and sympathetic nerve activity (SNA)
increase during a rise in central nervous system (CNS) Pco2 (central chemoreceptor …

Background Human breathing is regulated by feedback and feed-forward control
mechanisms, allowing a strict matching between metabolic needs and the uptake of oxygen …

The potential differences in cerebrovascular responses between the anterior and posterior
circulations to changes in CO 2 are unclear in humans. Using transcranial Doppler …

Sleep unmasks a highly sensitive hypocapnia‐induced apnoeic threshold, whereby apnoea
is initiated by small transient reductions in arterial CO2 pressure (PaCO2) below eupnoea …

We reviewed the ventilatory responses obtained from rebreathing experiments on a
population of 22 subjects. Our aim was to derive parameter estimates for an 'average …