The study of gene regulation has rapidly advanced by leveraging next-generation
sequencing to identify and characterize the cis and trans elements that are critical for …

In recent years, studies of cis-regulatory mechanisms have evolved from a predominant
focus on promoter regions to the realization that spatial and temporal gene regulation is …

There has been a recent surge in the use of genome-wide methodologies to identify and
annotate the transcriptional regulatory elements in the human genome. Here we review …

Enhancers are distally located genomic cis-regulatory elements that integrate
spatiotemporal cues to coordinate gene expression in a tissue-specific manner during …

Successful development depends on the precise tissue‐specific regulation of genes by
enhancers, genetic elements that act as switches to control when and where genes are …

Gene transcription is strictly controlled by the interplay of regulatory events at gene
promoters and gene‐distal regulatory elements called enhancers. Despite extensive studies …

Gene expression is regulated by numerous elements including enhancers, insulators,
transcription factors, and architectural proteins. Regions of DNA distal to the transcriptional …

Recent studies have shown that disease-susceptibility variants frequently lie in cell-type-
specific enhancer elements. To identify, interpret, and prioritize such risk variants, we must …

Large-scale sequencing studies discovered substantial genetic variants occurring in
enhancers which regulate genes via long range chromatin interactions. Importantly, such …

Enhancers are distal cis-regulatory DNA elements that increase the expression of target
genes. Various experimental and computational approaches including chromatin signature …