In this study, we have used the human BV173 and the mouse BaF3/Bcr-Abl-expressing cell
lines as model systems to investigate the molecular mechanisms whereby STI571 and …

Paclitaxel is used to treat breast cancers, but the mechanisms by which it induces apoptosis
are poorly understood. Consequently, we have studied the role of the FoxO transcription …

AZD6244 (ARRY-142886) is an inhibitor of MEK1/2 and can inhibit cell proliferation or
induce apoptosis in a cell-type dependent manner. The precise molecular mechanism of …

Chronic myeloid leukemia (CML) is a myeloproliferative disease in which BCR/ABL
enhances survival of leukemic cells through modulation of proapoptotic and antiapoptotic …

Bim is a proapoptotic member of the Bcl-2 family that shares only the BH3 domain with this
family. Three Bim proteins Bim-EL, Bim-L and Bim-S are synthesized from the same …

Bcr-Abl kinase is known to reverse apoptosis of cytokine-dependent cells due to cytokine
deprivation, although it has been controversial whether chronic myeloid leukemia (CML) …

BACKGROUND: Expression of the pro-apoptotic BCL-2-interacting mediator (BIM) has
recently been implicated in imatinib-induced apoptosis of BCR-ABL1+ cells. However, the …

As the infectious agent causing human adult T-cell leukemia (ATL), the human T-cell
leukemia virus type 1 (HTLV-1) virus spreads in vivo primarily by cell-to-cell transmission …

Impaired apoptosis is now recognized to be central to tumor development. Bcl2, activated by
chromosomal translocation in human follicular lymphoma, promotes oncogenesis by …

Histone deacetylase (HDAC) inhibitors have been shown to induce cell cycle arrest and
apoptosis in cancer cells. However, the mechanisms of HDAC inhibitor induced apoptosis …