Translating molecular discoveries into new therapies for atherosclerosis

DJ Rader, A Daugherty - Nature, 2008 - nature.com
Atherosclerosis is characterized by the thickening of the arterial wall and is the primary
cause of coronary artery disease and cerebrovascular disease, two of the most common …

Progress and challenges in translating the biology of atherosclerosis

P Libby, PM Ridker, GK Hansson - Nature, 2011 - nature.com
Atherosclerosis is a chronic disease of the arterial wall, and a leading cause of death and
loss of productive life years worldwide. Research into the disease has led to many …

The biology of atherosclerosis comes full circle: lessons for conquering cardiovascular disease

P Libby - Nature Reviews Cardiology, 2021 - nature.com
Atherosclerosis causes myocardial infarction, ischaemic cardiomyopathy, many ischaemic
strokes and jeopardized limbs. Despite enormous progress, atherosclerosis has become the …

The changing landscape of atherosclerosis

P Libby - Nature, 2021 - nature.com
Emerging evidence has spurred a considerable evolution of concepts relating to
atherosclerosis, and has called into question many previous notions. Here I review this …

Stabilization of atherosclerotic plaques: new mechanisms and clinical targets

P Libby, M Aikawa - Nature medicine, 2002 - nature.com
Research points to pivotal roles for lipids in the development of atherosclerotic plaques.
Lipid-lowering statins substantially reduce acute coronary events resulting from plaque …

Atherosclerosis: the path from genomics to therapeutics

DT Miller, PM Ridker, P Libby… - Journal of the American …, 2007 - jacc.org
Recent rapid advances in genomic tools and techniques hold great promise for transforming
the practice of cardiovascular medicine. Resources including the Human Genome Project …

Is it time to revise the HDL cholesterol hypothesis?

DJ Rader, AR Tall - Nature medicine, 2012 - nature.com
Formation of plaques in artery walls, or atherogenesis, is known to lead to cardiovascular
disease risk and heart disease. Low-density lipoproteins (LDLs), which deliver cholesterol to …

The pathogenesis of atherosclerosis: a perspective for the 1990s

R Ross - Nature, 1993 - nature.com
Atherosclerosis, the principal cause of heart attack, stroke and gangrene of the extremities,
is responsible for 50% of all mortality in the USA, Europe and Japan. The lesions result from …

Rapid regression of atherosclerosis: insights from the clinical and experimental literature

KJ Williams, JE Feig, EA Fisher - Nature clinical practice Cardiovascular …, 2008 - nature.com
Looking back at animal and clinical studies published since the 1920s, the notion of rapid
regression and stabilization of atherosclerosis in humans has evolved from a fanciful goal to …

[HTML][HTML] Regression of atherosclerosis: insights from animal and clinical studies

JE Feig - Annals of global health, 2014 - Elsevier
Background Based on studies that date back to the 1920s, regression and stabilization of
atherosclerosis in humans has gone from just a dream to one that is achievable. Review of …