Pharmacokinetic analysis provides information on the distribution and elimination of a drug
and facilitates the formulation of optimum dosing guidelines. Following the administration of …

BACKGROUND: With the growing use of pharmacokinetic (PK)-driven drug delivery and/or
drug advisory displays, identifying the PK model that best characterizes propofol plasma …

Induction of anesthesia with an intravenous hypnotic agent like propofol can be achieved by
administration of a manual bolus followed by a continuous infusion, with an infusion rate …

The pharmacology of the induction of anesthesia is still poorly understood and often roughly
described using compartmental modeling. The inability to describe and predict the plasma …

Background Conventional compartmental pharmacokinetic models wrongly assume
instantaneous drug mixing in the central compartment, resulting in a flawed prediction of …

Background Target-controlled infusion is an increasingly common type of administration for
propofol. This method requires accurate knowledge of pharmacokinetics, including the …

The disposition of the intravenous anesthetic propofol was studied when administered as a
constant rate infusion at 3, 6, and 9 mg [middle dot] kg1 [middle dot] hr-1 for at least 2 hr to …

The authors reflect on several issues and developments concerning pharmacokinetics (PK)
and pharmacodynamics (PD), and the need for a single PK-PD model for drugs like …

Intravenous injection of anesthetic drugs dates back to the 17th Century when opium and
chloral hydrate have been injected intravenously. It was not until the 1930s intravenous …

We have evaluated the clinical utility and blood propofol concentrations produced with two
dif ferent infusion regimens for propofol, given to supplement 67% nitrous oxide-morphine …