β-arrestins (βarrs), initially discovered as desensitizers of GPCR signaling, are now known
to function as intracellular scaffolds and signaling transducers mediating a wide array of …

Introduction: In response to Coxsackievirus B3 (CVB3) infection, immune cells infiltrate the
heart affecting viral clearance, tissue damage, and cardiac remodeling. However, the …

Beta-arrestins (β-arrestin1 and β-arrestin2) are known as cytosolic proteins that mediate
desensitization and internalization of activated G protein-coupled receptors. In addition to …

Abstract β-Arrestins are a highly conserved family of cytosolic adaptor proteins that
contribute to many immune functions by orchestrating the desensitization and internalization …

Aims Ischemic heart disease is a leading cause of morbidity and mortality worldwide.
Although timely restoration of coronary blood flow (reperfusion) is the most effective …

Abstract β-Arrestins regulate G protein-coupled receptors through receptor desensitization
while also acting as signaling scaffolds to facilitate numerous effector pathways. Recent …

β-Arrestin-1 (βArr1), a scaffolding protein critical in G-protein coupled receptor
desensitization has more recently been found to be important in the pathogenesis of various …

β-arrestin1 and β-arrestin2 were initially identified by sequence homology to visual arrestins
and by their ability to bind to and inactivate signaling of the beta-2-adrenergic receptor in a …

The two ubiquitous, outside the retina, G protein-coupled receptor (GPCR) adapter proteins,
β-arrestin-1 and-2 (also known as arrestin-2 and-3, respectively), have three major functions …

Heart failure is the leading cause of death in the Western world, and new and innovative
treatments are needed. The GPCR (G protein–coupled receptor) adapter proteins βarr (β …