B cells are highly potent antigen presenting cells of their cognate antigens. However, it
remains unknown whether B cells can orchestrate Th17-mediated responses against neuro …

Both T cells and B cells are implicated in the pathology of multiple sclerosis (MS), but how
these cells cooperate to drive disease remains unclear. Recent studies using experimental …

Objective There is substantial evidence supporting the role of interferon (IFN)‐γ–producing T
helper (TH) 1 and interleukin (IL)‐17–expressing TH17 lymphocytes in multiple sclerosis …

The efficacy of rituximab treatment in multiple sclerosis has renewed interest in the role of B
cells in CNS autoimmunity. In this study, we show that B cells are the predominant MHC …

The contribution of B cells to the pathogenesis of relapsing-remitting multiple sclerosis
(RRMS) is currently of great interest due to the positive outcomes of treatment with B cell …

Myelin-reactive T helper-17 cells are implicated in the pathogenesis of multiple sclerosis
(MS). Here, we analyzed the reactivity of peripheral naive and memory conventional CD4+ …

Multiple sclerosis is a T cell-mediated demyelinating disease of the central nervous system.
Interleukin-17-producing T helper cells, named Th17 cells, represent a novel CD4+ T cell …

T-bet enhances the encephalitogenicity of myelin-reactive CD4+ T cells, however its
mechanism of action is unknown. In this study we show that T-bet confers a competitive …

Th17 cells, known as a highly pro-inflammatory subtype of Th cells, are involved very early
in numerous aspects of multiple sclerosis (MS) and experimental autoimmune …

In this study, acute and chronic brain and spinal cord lesions, and normal appearing white
matter (NAWM), were resected post-mortem from a patient with aggressive relapsing …