Regulation of lung injury and repair by Toll-like receptors and hyaluronan
Mechanisms that regulate inflammation and repair after acute lung injury are incompletely
understood. The extracellular matrix glycosaminoglycan hyaluronan is produced after tissue …
understood. The extracellular matrix glycosaminoglycan hyaluronan is produced after tissue …
Matrix regulation of lung injury, inflammation, and repair: the role of innate immunity
PW Noble, D Jiang - Proceedings of the American Thoracic Society, 2006 - atsjournals.org
Mechanisms that regulate host defense after noninfectious tissue injury are incompletely
understood. Our laboratory is interested in the role of the extracellular matrix …
understood. Our laboratory is interested in the role of the extracellular matrix …
Hyaluronan in tissue injury and repair
A hallmark of tissue injury and repair is the turnover of extracellular matrix components. This
review focuses on the role of the glycosaminoglycan hyaluronan in tissue injury and repair …
review focuses on the role of the glycosaminoglycan hyaluronan in tissue injury and repair …
[HTML][HTML] The role of Toll-like receptors in non-infectious lung injury
The role of Toll-like receptors (TLRs) in pathogen recognition has been expeditiously
advanced in recent years. However, investigations into the function of TLRs in non-infectious …
advanced in recent years. However, investigations into the function of TLRs in non-infectious …
Hyaluronan and TLR4 promote surfactant-protein-C-positive alveolar progenitor cell renewal and prevent severe pulmonary fibrosis in mice
Successful recovery from lung injury requires the repair and regeneration of alveolar
epithelial cells to restore the integrity of gas-exchanging regions within the lung and …
epithelial cells to restore the integrity of gas-exchanging regions within the lung and …
Hyaluronan as an immune regulator in human diseases
Accumulation and turnover of extracellular matrix components are the hallmarks of tissue
injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety …
injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety …
TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury
S Hussain, CG Johnson, J Sciurba, X Meng, VP Stober… - Elife, 2020 - elifesciences.org
Lung disease causes significant morbidity and mortality, and is exacerbated by
environmental injury, for example through lipopolysaccharide (LPS) or ozone (O3). Toll-like …
environmental injury, for example through lipopolysaccharide (LPS) or ozone (O3). Toll-like …
Hyaluronan fragments act as an endogenous danger signal by engaging TLR2
KA Scheibner, MA Lutz, S Boodoo… - The Journal of …, 2006 - journals.aai.org
Upon tissue injury, high mw hyaluronan (HA), a ubiquitously distributed extracellular matrix
component, is broken down into lower mw (LMW) fragments, which in turn activate an innate …
component, is broken down into lower mw (LMW) fragments, which in turn activate an innate …
[HTML][HTML] Hyaluronan and its interactions with immune cells in the healthy and inflamed lung
Hyaluronan is a hygroscopic glycosaminoglycan that contributes to both extracellular and
pericellular matrices. While the production of hyaluronan is essential for mammalian …
pericellular matrices. While the production of hyaluronan is essential for mammalian …
Engagement of CD44 by hyaluronan suppresses TLR4 signaling and the septic response to LPS
Fragments of hyaluronan released after injury bind and activate TLR4 in a complex with
CD44. Here we investigated if the recognition of hyaluronan by CD44 and TLR4 alters …
CD44. Here we investigated if the recognition of hyaluronan by CD44 and TLR4 alters …