Abstract The Dobzhansky–Muller (DM) model provides a widely accepted mechanism for
the evolution of reproductive isolation: incompatible substitutions disrupt interactions …

One approach to understanding the process of speciation is to characterize the genetic
architecture of post-zygotic isolation. As gene regulation requires interactions between loci …

Mapping hybrid defects in contact zones between incipient species can identify genomic
regions contributing to reproductive isolation and reveal genetic mechanisms of speciation …

Hybrid dysfunction, a common feature of reproductive barriers between species, is often
caused by negative epistasis between loci (“Dobzhansky-Muller incompatibilities”). The …

Reproductive isolation is often caused by the disruption of genic interactions that evolve in
geographically separate populations. Identifying the genomic regions and genes involved in …

Identification of the genes that underlie reproductive isolation provides important insights
into the process of speciation. According to the Dobzhansky–Muller model, these genes …

Studies of a hybrid zone between two house mouse subspecies (Mus musculus musculus
and M. m. domesticus) along with studies using laboratory crosses reveal a large role for the …

Understanding the molecular basis of species formation is an important goal in evolutionary
genetics, and Dobzhansky-Muller incompatibilities are thought to be a common source of …

Barriers to gene flow between naturally hybridizing taxa reveal the initial stages of
speciation. Reduced hybrid fertility is a common feature of reproductive barriers separating …

Comparative genetic mapping provides insights into the evolution of the reproductive
barriers that separate closely related species. This approach has been used to document …