Some cases of Alzheimer's disease are inherited as an autosomal dominant trait. Genetic
linkage studies have mapped a locus (AD3) associated with susceptibility to a very …

WE report the cloning of a novel gene (E5-1) encoded on chromosome 1 which has
substantial nucleotide and amino-acid sequence similarity to the S182 gene on …

A LOCUS segregating with familial Alzheimer's disease (AD) has been mapped to
chromosome 21 (ref. 1), close to the amyloid precursor protein (APP) gene2–5 …

The gene coding for the amyloid protein, a component of neuritic plaques found in brain
tissue from patients with Alzheimer's disease, has been localized to chromosome 21, and …

Amyloid β-protein (AP) is a peptide of relative molecular mass (M r) 42,000 found in the
senile plaques, cerebrovascular amyloid deposits, and neurofibrillary tangles of patients …

ALZHEIMER'S disease, a fatal neurodegenerative disorder of unknown aetiology, is usually
considered to be a single disorder because of tbe general uniformity of the disease …

Familial Alzheimer's disease (FAD) has been shown to be genetically heterogeneous, with a
very small proportion of early onset pedigrees being associated with mutations in the …

A MUTATION at codon 717 of the β-amyloid precursor protein gene has been found to
cosegregate with familial Alzheimer's disease in a single family1. This mutation has been …

The possibility that Alzheimer's disease (AD) is caused by overexpression or duplication of
one or more genes on chromosome 21 has been raised by the observation of AD-like …

Genetic linkage studies with chromosome 21 DNA markers and mutation analysis of the β–
amyloid protein precursor gene located in 21q21. 3 have indicated that early–onset …