Pathobiology of pulmonary arterial hypertension and right ventricular failure

NF Voelkel, J Gomez-Arroyo, A Abbate… - European …, 2012 - Eur Respiratory Soc
Pulmonary arterial hypertension (PAH) is no longer an orphan disease. There are three
different classes of drugs for the treatment of PAH that are currently being used and an …

Right ventricular adaptation and failure in pulmonary arterial hypertension

JJ Ryan, J Huston, S Kutty, ND Hatton… - Canadian Journal of …, 2015 - Elsevier
Pulmonary arterial hypertension (PAH) is an obstructive pulmonary vasculopathy,
characterized by excess proliferation, apoptosis resistance, inflammation, fibrosis, and …

The right ventricle in pulmonary hypertension

KM Chin, NHS Kim, LJ Rubin - Coronary artery disease, 2005 - journals.lww.com
Pulmonary arterial hypertension (PAH) is a term used to classify a variety of conditions that
share in common an injury to the pulmonary vasculature that produces elevations in …

Signal transduction in the development of pulmonary arterial hypertension

S Malenfant, AS Neyron, R Paulin… - Pulmonary …, 2013 - journals.sagepub.com
Pulmonary arterial hypertension (PAH) is a unique disease. Properly speaking, it is not a
disease of the lung. It can be seen more as a microvascular disease occurring mainly in the …

The right ventricle in pulmonary arterial hypertension

R Naeije, A Manes - European respiratory review, 2014 - Eur Respiratory Soc
Pulmonary arterial hypertension (PAH) is a right heart failure syndrome. In early-stage PAH,
the right ventricle tends to remain adapted to afterload with increased contractility and little …

The role of the right ventricle in pulmonary arterial hypertension

AV Noordegraaf, N Galiè - European Respiratory Review, 2011 - Eur Respiratory Soc
Although changes in the pulmonary vasculature are the primary cause of pulmonary arterial
hypertension (PAH), severity of symptoms and survival are strongly associated with right …

The right ventricle under pressure: cellular and molecular mechanisms of right-heart failure in pulmonary hypertension

HJ Bogaard, K Abe, AV Noordegraaf, NF Voelkel - Chest, 2009 - Elsevier
Pulmonary arterial hypertension (PAH) is a deadly disease in which vasoconstriction and
vascular remodeling both lead to a progressive increase in pulmonary vascular resistance …

Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology

A Vonk-Noordegraaf, F Haddad, KM Chin… - Journal of the American …, 2013 - jacc.org
Survival in patients with pulmonary arterial hypertension (PAH) is closely related to right
ventricular (RV) function. Although pulmonary load is an important determinant of RV …

Pulmonary hypertension in heart failure: pathophysiology, pathobiology, and emerging clinical perspectives

M Guazzi, R Naeije - Journal of the American College of Cardiology, 2017 - jacc.org
Pulmonary hypertension is a common hemodynamic complication of heart failure. Interest in
left-sided pulmonary hypertension has increased remarkably in recent years because its …

Right heart failure in pulmonary hypertension

SJ Cassady, GV Ramani - Cardiology clinics, 2020 - cardiology.theclinics.com
Pulmonary hypertension (PH), previously defined as a mean pulmonary artery pressure of
greater than 25 mm Hg, has recently been redefined by the Sixth World Symposium on …