Establishing an immunocompromised porcine model of human cancer for novel therapy development with pancreatic adenocarcinoma and irreversible …

A Hendricks-Wenger, KN Aycock, MA Nagai-Singer… - Scientific reports, 2021 - nature.com
New therapies to treat pancreatic cancer are direly needed. However, efficacious
interventions lack a strong preclinical model that can recapitulate patients' anatomy and …

Patient Derived Xenografts Expand Human Primary Pancreatic Tumor Tissue Availability for ex vivo Irreversible Electroporation Testing

RM Brock, N Beitel-White, S Coutermarsh-Ott… - Frontiers in …, 2020 - frontiersin.org
New methods of tumor ablation have shown exciting efficacy in pre-clinical models but often
demonstrate limited success in the clinic. Due to a lack of quality or quantity in primary …

A syngeneic pancreatic cancer mouse model to study the effects of irreversible electroporation

JSS Narayanan, P Ray, I Naqvi, R White - JoVE (Journal of Visualized …, 2018 - jove.com
Pancreatic cancer (PC), a disease which kills approximately 40,000 patients each year in
the US, has successfully evaded several therapeutic approaches including the promising …

Efficacy of irreversible electroporation in human pancreatic adenocarcinoma: advanced murine model

P Philips, Y Li, S Li, CR St Hill, RCG Martin - Molecular therapy Methods & …, 2015 - cell.com
Irreversible electroporation (IRE) is a promising cell membrane ablative modality for
pancreatic cancer. There have been recent concerns regarding local recurrence and the …

Physical and chemical enhancement of and adaptive resistance to irreversible electroporation of pancreatic cancer

Q Shao, F Liu, C Chung, K Elahi-Gedwillo… - Annals of biomedical …, 2018 - Springer
Irreversible electroporation (IRE) can be used to treat cancer by electrical pulses, with
advantages over traditional thermal approaches. Here we assess for the first time the IRE …

Modeling of irreversible electroporation treatments for the optimization of pancreatic cancer therapies

EL Latouche, RV Davalos, RCG Martin - 6th European Conference of the …, 2015 - Springer
Irreversible Electroporation (IRE) is a minimally invasive non-thermal ablation technique that
can be used to eradicate tumors and other undesirable tissue. IRE consists of a series of …

Irreversible electroporation in pancreatic cancer—An evolving experimental and clinical method

A Gajewska-Naryniecka, U Szwedowicz… - International Journal of …, 2023 - mdpi.com
Pancreatic cancer has no symptoms until the disease has advanced and is aggressive
cancer with early metastasis. Up to now, the only curative treatment is surgical resection …

T‐cell activation and immune memory enhancement induced by irreversible electroporation in pancreatic cancer

C He, X Huang, Y Zhang, X Lin… - Clinical and translational …, 2020 - Wiley Online Library
Background Irreversible electroporation is shown to induce immune changes in pancreatic
cancer while the histology evidences are still lacking. The aim of this study is to show the …

Immunomodulatory effect of irreversible electroporation alone and its cooperating with immunotherapy in pancreatic cancer

G Tian, J Guan, Y Chu, Q Zhao, T Jiang - Frontiers in Oncology, 2021 - frontiersin.org
Emerging studies have showed irreversible electroporation (IRE) focused on pancreatic
cancer (PC). However, the effects of IRE treatment on the immune response of PC remain …

A three-dimensional in vitro tumor platform for modeling therapeutic irreversible electroporation

CB Arena, CS Szot, PA Garcia, MN Rylander… - Biophysical journal, 2012 - cell.com
Irreversible electroporation (IRE) is emerging as a powerful tool for tumor ablation that
utilizes pulsed electric fields to destabilize the plasma membrane of cancer cells past the …