The spinal cord is the initial stage that integrates temperature information from peripheral
inputs. Here we used molecular genetics and in vivo calcium imaging to investigate the …

Defending body temperature against environmental thermal challenges is one of the most
fundamental homeostatic functions that are governed by the nervous system. Here we …

Humans detect skin temperature changes that are perceived as warm or cool. Like humans,
mice report forepaw skin warming with perceptual thresholds of less than 1° C and do not …

Afferent neural transmission of temperature sensation from skin thermoreceptors to the
central thermoregulatory system is important for the defense of body temperature against …

Perception of the thermal environment begins with the activation of peripheral
thermosensory neurons innervating the body surface. To understand how temperature is …

Temperature is a fundamental sensory modality separate from touch, with dedicated
receptor channels and primary afferent neurons for cool and warm,–. Unlike for other …

When temperature (T) of skin decreases stepwise, cold fibers evoke transient afferent
discharges, inducing cold sensation and heat-gain responses. Hence we have proposed …

Temperature transduction in mammals is possible because of the presence of a set of
temperature-dependent transient receptor potential (TRP) channels in dorsal root ganglia …

The temperature of an object provides important somatosensory information for animals
performing tactile tasks. Humans can perceive skin cooling of less than one degree, but the …

Neurons of the peripheral nervous system detect changes in temperature through activation
of specialised ion channels. Members of the transient receptor potential family TRPM8 and …