In the present study, a series of 1, 4-naphthoquinone oxime derivatives has been
synthesized. The structures were confirmed by spectroscopic methods. The newly …

As a continuous study, a set of 23 new 6-substituted 1, 4-naphthoquinone oxime derivatives
are synthesized and screened for their in vitro cytotoxic activity. Four of those oxime …

Abstract A series of hydroxylated 1, 4-naphthoquinone oximes were designed and
synthesized. The in vitro cytotoxicity of these compounds was evaluated against five human …

Abstract A series of 6-substituted 1, 4-naphthoquinone oxime derivatives were synthesized
and evaluated for their in vitro cytotoxicity against four cancer cell lines and one normal cell …

The cancer is among the most important diseases of our time, being the second leading
cause of death in developed countries. The development of more effective …

New substituted 1, 4-naphthoquinones have been prepared in good overall yields through
the naphthol route. The cytotoxicity of these compounds was tested in vitro on MCF-7 breast …

In an effort to develop potent and selective antitumor agents, a series of 1, 4-
naphthoquinone oxime derivatives were designed and synthesized. The cytotoxicity of these …

Synthesized ranks of new biologically active compounds by nucleophilic substitution of
chlorine atom in the amino acid chloride derivatives of 1, 4-naphthoquinone. All structures …

An alternative to finding new drugs for the treatment of various diseases is the chemical
modification of the structure of compounds of natural origin. Among them, naphthoquinones …

All of 13 (E)-6-(1-alkyloxyiminomethyl)-5, 8-dimethoxy-1, 4-naphthoquinone derivatives
synthesized showed high ED50 values, ranging from 0.1 to 0.3 μg/mL against L1210 cells …