Muscular dystrophies (MDs) comprise a group of degenerative muscle disorders
characterized by progressive muscle wasting and often premature death. The primary defect …

Duchenne muscular dystrophy (DMD) is characterized by progressive muscle wasting
secondary to repeated muscle damage and inadequate repair. Elevations in intracellular …

Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder characterized by
progressive muscular weakness because of the loss of dystrophin. Extracellular Ca2+ flows …

Loss of dystrophin leads to Duchenne muscular dystrophy (DMD). A pathogenic feature of
DMD is the significant elevation of cytosolic calcium. Supraphysiological calcium triggers …

Although the precise pathophysiological mechanism of muscle damage in dystrophin-
deficient muscle remains disputed, calcium appears to be a critical mediator of the …

Abnormal intracellular Ca 2+ handling is an important factor in the progressive functional
decline of dystrophic muscle. In the present study, we investigated the function of sarco …

Background Cardiomyocyte calcium overloading has been implicated in the pathogenesis of
Duchenne muscular dystrophy (DMD) heart disease. The cardiac isoform of sarcoplasmic …

Sarcolipin (SLN) is an inhibitor of the sarco/endoplasmic reticulum (SR) Ca2+ ATPase
(SERCA) and is abnormally elevated in the muscle of Duchenne muscular dystrophy (DMD) …

Sarcoglycans are a group of single-pass transmembrane glycoproteins. In striated muscle,
sarcoglycans interact with dystrophin and other dystrophin-associated proteins (DAPs) to …

γ-Sarcoglycan is a transmembrane, dystrophin-associated protein expressed in skeletal and
cardiac muscle. The murine γ-sarcoglycan gene was disrupted using homologous …