Neuroadaptations in the cellular and postsynaptic group 1 metabotropic glutamate receptor mGluR5 and Homer proteins following extinction of cocaine self …
MB Ghasemzadeh, P Vasudevan, C Mueller… - Neuroscience …, 2009 - Elsevier
This study examined the role of group1 metabotropic glutamate receptor mGluR5 and
associated postsynaptic scaffolding protein Homer1b/c in behavioral plasticity after three …
associated postsynaptic scaffolding protein Homer1b/c in behavioral plasticity after three …
Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seeking
LA Knackstedt, K Moussawi, R Lalumiere… - Journal of …, 2010 - Soc Neuroscience
Learning to inhibit drug seeking can be an important strategy for inhibiting relapse, and this
can be modeled by extinguishing drug seeking in response to a drug-paired context. Rats …
can be modeled by extinguishing drug seeking in response to a drug-paired context. Rats …
Effects of mGluR1 antagonism in the dorsal hippocampus on drug context-induced reinstatement of cocaine-seeking behavior in rats
X Xie, DR Ramirez, HC Lasseter, RA Fuchs - Psychopharmacology, 2010 - Springer
Rationale The functional integrity of the dorsal hippocampus (DH) is necessary for drug
context-induced reinstatement of cocaine seeking. However, the neuropharmacological …
context-induced reinstatement of cocaine seeking. However, the neuropharmacological …
Repeated cocaine administration attenuates group I metabotropic glutamate receptor-mediated glutamate release and behavioral activation: a potential role for Homer
CJ Swanson, DA Baker, D Carson… - Journal of …, 2001 - Soc Neuroscience
The present study aimed to characterize a functional role for group I metabotropic glutamate
receptors (mGluRs) in the nucleus accumbens and the capacity of repeated cocaine to elicit …
receptors (mGluRs) in the nucleus accumbens and the capacity of repeated cocaine to elicit …
Role of mGluR5 neurotransmission in reinstated cocaine‐seeking
X Wang, K Moussawi, L Knackstedt, H Shen… - Addiction …, 2013 - Wiley Online Library
In animal models of addiction, reducing glutamate stimulation of the metabotropic glutamate
receptor 5 (mGluR5) inhibits drug‐seeking. The present study used the reinstatement model …
receptor 5 (mGluR5) inhibits drug‐seeking. The present study used the reinstatement model …
Synaptic depotentiation and mGluR5 activity in the nucleus accumbens drive cocaine-primed reinstatement of place preference
MA Benneyworth, MC Hearing, AJ Asp… - Journal of …, 2019 - Soc Neuroscience
Understanding the neurobiological processes that incite drug craving and drive relapse has
the potential to help target efforts to treat addiction. The NAc serves as a critical substrate for …
the potential to help target efforts to treat addiction. The NAc serves as a critical substrate for …
Incentive learning underlying cocaine-seeking requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons
M Novak, B Halbout, EC O'Connor… - Journal of …, 2010 - Soc Neuroscience
Understanding the psychobiological basis of relapse remains a challenge in developing
therapies for drug addiction. Relapse in cocaine addiction often occurs following exposure …
therapies for drug addiction. Relapse in cocaine addiction often occurs following exposure …
The role of ventral and dorsal striatum mGluR5 in relapse to cocaine‐seeking and extinction learning
LA Knackstedt, HL Trantham‐Davidson… - Addiction …, 2014 - Wiley Online Library
Cocaine addiction is a chronic, relapsing disease characterized by an inability to regulate
drug‐seeking behavior. Here we investigated the role of mGluR5 in the ventral and dorsal …
drug‐seeking behavior. Here we investigated the role of mGluR5 in the ventral and dorsal …
Enhanced cocaine responsiveness and impaired motor coordination in metabotropic glutamate receptor subtype 2 knockout mice
Y Morishima, T Miyakawa… - Proceedings of the …, 2005 - National Acad Sciences
Extensive pharmacological studies have recently emerged indicating that group 2
metabotropic glutamate receptors (mGluRs) comprising mGluR2 and mGluR3 subtypes are …
metabotropic glutamate receptors (mGluRs) comprising mGluR2 and mGluR3 subtypes are …
Incubation of cocaine seeking following brief cocaine experience in mice is enhanced by mGluR1 blockade
B Halbout, RE Bernardi, AC Hansson… - Journal of …, 2014 - Soc Neuroscience
The incubation of cocaine craving describes the time-dependent augmentation of cue-
induced cocaine seeking during withdrawal from prolonged cocaine self-administration and …
induced cocaine seeking during withdrawal from prolonged cocaine self-administration and …