Homogeneous conjugation of peptides onto gold nanoparticles enhances macrophage response

NG Bastús, E Sánchez-Tilló, S Pujals, C Farrera… - ACS …, 2009 - ACS Publications
Murine bone marrow macrophages were able to recognize gold nanoparticle peptide
conjugates, while peptides or nanoparticles alone were not recognized. Consequently, in …

Peptides conjugated to gold nanoparticles induce macrophage activation

NG Bastús, E Sánchez-Tilló, S Pujals, C Farrera… - Molecular …, 2009 - Elsevier
Macrophages that react against pathogenic organisms can also be activated with artificial
nanometric units consisting of gold nanoparticles (Au NPs) with a peptide coating. Using …

High-density sub-100-nm peptide-gold nanoparticle complexes improve vaccine presentation by dendritic cells in vitro

AY Lin, J Lunsford, AS Bear, JK Young… - Nanoscale Research …, 2013 - Springer
Nanocarriers have been explored to improve the delivery of tumor antigens to dendritic cells
(DCs). Gold nanoparticles are attractive nanocarriers because they are inert, non-toxic, and …

Manipulating immune activation of macrophages by tuning the oligonucleotide composition of gold nanoparticles

RM Pallares, P Choo, LE Cole, CA Mirkin… - Bioconjugate …, 2019 - ACS Publications
This paper describes how the ligand shell containing immunostimulatory oligonucleotides
surrounding gold nanoparticles affects the in vitro activation of macrophages …

Endosomal pH modulation by peptide-gold nanoparticle hybrids enables potent anti-inflammatory activity in phagocytic immune cells

H Yang, L Kozicky, A Saferali, SY Fung, N Afacan… - Biomaterials, 2016 - Elsevier
Toll-like receptor (TLR) signaling plays a central role in the pathophysiology of many acute
and chronic human inflammatory diseases, and pharmacological regulation of TLR …

Influence of gold nanoparticles with different surface charges on localization and monocyte behavior

S Srijampa, S Buddhisa, S Ngernpimai… - Bioconjugate …, 2020 - ACS Publications
The use of gold nanoparticles (AuNP) has been established in nanocarriers, diagnostics,
and biosensors. Access to the targeted sites of these nanomaterials could directly involve …

Small molecule–gold nanorod conjugates selectively target and induce macrophage cytotoxicity towards breast cancer cells

EC Dreaden, SC Mwakwari, LA Austin, MJ Kieffer… - Small, 2012 - Wiley Online Library
Gold nanoparticles have demonstrated tremendous utility and multifunctionality for the
diagnosis and treatment of cancer.[1] Not only can these structures serve as targeted drug …

Rapid uptake of gold nanorods by primary human blood phagocytes and immunomodulatory effects of surface chemistry

M Bartneck, HA Keul, S Singh, K Czaja, J Bornemann… - ACS …, 2010 - ACS Publications
Nanoparticle-based in vivo applications should consider the omnipresence of the
phagocytes in the bloodstream and tissue. We have studied the nanoparticle uptake …

Cellular uptake and fate of PEGylated gold nanoparticles is dependent on both cell-penetration peptides and particle size

E Oh, JB Delehanty, KE Sapsford, K Susumu… - ACS …, 2011 - ACS Publications
Numerous studies have examined how the cellular delivery of gold nanoparticles (AuNPs) is
influenced by different physical and chemical characteristics; however, the complex …

Targeted immunomodulation using antigen‐conjugated nanoparticles

DP McCarthy, ZN Hunter, B Chackerian… - Wiley …, 2014 - Wiley Online Library
The growing prevalence of nanotechnology in the fields of biology, medicine, and the
pharmaceutical industry is confounded by the relatively small amount of data on the impact …