Acetaminophen (AAP) overdose can cause severe hepatotoxicity and even liver failure in
experimental animals and humans. Despite substantial efforts over the last 30 years, the …

Acetaminophen (APAP) overdose is the most frequent cause of liver injury and acute liver
failure in many western countries. The mechanism of APAP-induced hepatocyte necrosis …

Significance: Acetaminophen (APAP) is one of the quantitively most consumed drugs
worldwide. Although safe at therapeutic doses, intentional or unintentional overdosing …

Peroxynitrite may be involved in acetaminophen-induced liver damage. However, it is
unclear if peroxynitrite is generated in hepatocytes or in the vasculature. To address this …

Acetaminophen (APAP) was first synthesized in the 1800s, and came on the market
approximately 65 years ago. Since then, it has become one of the most used drugs in the …

Acetaminophen (AAP) overdose causes formation of nitrotyrosine, a footprint of peroxynitrite,
in centrilobular hepatocytes. The importance of peroxynitrite for the pathophysiology …

Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the
West. In mice, APAP hepatotoxicity can be rapidly induced with a single dose. Because it is …

Large doses of the analgesic acetaminophen cause centrilobular hepatic necrosis in man
and in experimental animals. It has been previously shown that acetaminophen is …

Mitochondrial oxidant stress and peroxynitrite formation have been implicated in the
pathophysiology of acetaminophen-induced (AAP-induced) liver injury. Therefore, we tested …

There is a significant need to evaluate the therapeutic potential of natural products and other
compounds purported to be hepatoprotective. Acetaminophen-induced liver injury …