Approaches exploiting trait distribution extremes may be used to identify loci associated with
common traits, but it is unknown whether these loci are generalizable to the broader …

To identify genetic loci influencing central obesity and fat distribution, we performed a meta-
analysis of 16 genome-wide association studies (GWAS, N= 38,580) informative for adult …

Obesity is a major public health problem with strong genetic determination. Multiple genetic
variants have been implicated for obesity by conducting genome-wide association (GWA) …

Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic
consequences independent of overall adiposity. WHR is heritable, but few genetic variants …

Background Thirty-two common variants associated with body mass index (BMI) have been
identified in genome-wide association studies, explaining∼ 1.45% of BMI variation in …

Obesity results from the interaction of genetic and environmental factors. To search for
sequence variants that affect variation in two common measures of obesity, weight and body …

Genome-wide association studies (GWAS) have identified> 250 loci for body mass index
(BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters …

Multiple genetic loci associated with obesity or body mass index (BMI) have been identified
through genome-wide association studies conducted predominantly in populations of …

Obesity is an important factor contributing to the global burden of morbidity and mortality. By
identifying obesity susceptibility genes, scientists aim to elucidate some of its aetiology …

Meta-analyses of population-based genome-wide association studies (GWAS) in adults
have recently led to the detection of new genetic loci for obesity. Here we aimed to discover …