[HTML][HTML] Suppression of EGF-R signaling reduces the incidence of prostate cancer metastasis in nude mice
The activation of epidermal growth factor receptor (EGF-R) plays a key role in the promotion
of proliferation and invasion in prostatic carcinoma (PCa). Gefitinib (Iressa; ZD1839), an …
of proliferation and invasion in prostatic carcinoma (PCa). Gefitinib (Iressa; ZD1839), an …
Gefitinib ('IRESSA', ZD1839) inhibits EGF-induced invasion in prostate cancer cells by suppressing PI3 K/AKT activation
Purpose Androgen-independent prostate cancer (AI-PC) is characterized by a higher
invasive potential compared to hormone-responsive prostate cancer. A therapeutic option …
invasive potential compared to hormone-responsive prostate cancer. A therapeutic option …
Targeted inhibition of the epidermal growth factor receptor‐tyrosine kinase by ZD1839 ('Iressa') induces cell‐cycle arrest and inhibits proliferation in prostate cancer …
A Sgambato, A Camerini, B Faraglia… - Journal of cellular …, 2004 - Wiley Online Library
The epidermal growth factor (EGF) plays a role in the development of prostate cancer, which
becomes essential after androgen resistance has emerged. The EGF receptor (EGFR) is …
becomes essential after androgen resistance has emerged. The EGF receptor (EGFR) is …
Targeting of EGFR tyrosine kinase by ZD1839 (“Iressa”) in androgen-responsive prostate cancer in vitro
I Bellezza, S Bracarda, C Caserta, A Minelli - Molecular genetics and …, 2006 - Elsevier
EGFR, highly expressed in a variety of human malignancies, is correlated with poor tumour
differentiation, high tumour growth and metastatic rate. EGF and several other ligands, such …
differentiation, high tumour growth and metastatic rate. EGF and several other ligands, such …
Signaling mechanisms that mediate invasion in prostate cancer cells
Recent evidence indicates that androgen‐sensitive prostate cancer cells have a less
malignant phenotype characterized by reduced migration and invasion. We investigated …
malignant phenotype characterized by reduced migration and invasion. We investigated …
Prostate cancer cell proliferation is strongly reduced by the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in vitro on human cell lines and primary …
C Vicentini, C Festuccia, GL Gravina… - Journal of cancer …, 2003 - Springer
Purpose. To investigate the effects of the epidermal growth factor receptor tyrosine kinase
inhibitor (EGFR-TKI) ZD1839 ('Iressa') on the cellular proliferation of androgen-sensitive and …
inhibitor (EGFR-TKI) ZD1839 ('Iressa') on the cellular proliferation of androgen-sensitive and …
Novel combination therapy against metastatic and androgen‐independent prostate cancer by using gefitinib, tamoxifen and etoposide
M Mimeault, G Venkatraman… - … journal of cancer, 2007 - Wiley Online Library
In this study, we evaluated, for the first time, the antiproliferative and cytotoxic effects induced
by a combination of a selective epidermal growth factor receptor (EGFR) tyrosine kinase …
by a combination of a selective epidermal growth factor receptor (EGFR) tyrosine kinase …
Blockade of epidermal growth factor receptor signaling in tumor cells and tumor-associated endothelial cells for therapy of androgen-independent human prostate …
SJ Kim, H Uehara, T Karashima, DL Shepherd… - Clinical cancer …, 2003 - AACR
Purpose: We determined whether blockade of the epidermal growth factor receptor (EGF-R)
signaling pathway by oral administration of the EGF-R tyrosine kinase inhibitor (PKI 166) …
signaling pathway by oral administration of the EGF-R tyrosine kinase inhibitor (PKI 166) …
Anti-EGF receptor therapy
G Blackledge, S Averbuch, A Kay… - Prostate Cancer and …, 2000 - nature.com
The epidermal growth factor receptor (EGFR) signalling pathway contributes to a number of
processes important to tumour progression, including cell proliferation, apoptosis …
processes important to tumour progression, including cell proliferation, apoptosis …
EGF receptor (EGFR) signaling promoting invasion is disrupted in androgen‐sensitive prostate cancer cells by an interaction between EGFR and androgen receptor …
L Bonaccorsi, V Carloni, M Muratori… - … Journal of Cancer, 2004 - Wiley Online Library
We previously demonstrated that expression of androgen receptor (AR) by transfection of
the androgen‐independent prostate cancer cell line PC3 decreases invasion and adhesion …
the androgen‐independent prostate cancer cell line PC3 decreases invasion and adhesion …