Role of oxidative stress in metabolic and subcellular abnormalities in diabetic cardiomyopathy

NS Dhalla, AK Shah, PS Tappia - International journal of molecular …, 2020 - mdpi.com
Although the presence of cardiac dysfunction and cardiomyopathy in chronic diabetes has
been recognized, the pathophysiology of diabetes-induced metabolic and subcellular …

Current understanding of structural and molecular changes in diabetic cardiomyopathy

MS Akhtar, SS Alavudeen, A Raza, MT Imam… - Life Sciences, 2023 - Elsevier
Diabetic Mellitus has been characterized as the most prevalent disease throughout the
globe associated with the serious morbidity and mortality of vital organs. Cardiomyopathy is …

Mechanisms of subcellular remodeling in heart failure due to diabetes

NS Dhalla, N Takeda, D Rodriguez-Leyva… - Heart failure …, 2014 - Springer
Diabetic cardiomyopathy is not only associated with heart failure but there also occurs a loss
of the positive inotropic effect of different agents. It is now becoming clear that cardiac …

Molecular and cellular basis of the aetiology and management of diabetic cardiomyopathy: a short review

E Adeghate - Molecular and cellular biochemistry, 2004 - Springer
Diabetes mellitus is one of the most common chronic diseases affecting millions of people
worldwide. Cardiovascular complication including myocardial infarction is one of the major …

Contribution of impaired insulin signaling to the pathogenesis of diabetic cardiomyopathy

M Zamora, JA Villena - International journal of molecular sciences, 2019 - mdpi.com
Diabetic cardiomyopathy (DCM) has emerged as a relevant cause of heart failure among the
diabetic population. Defined as a cardiac dysfunction that develops in diabetic patients …

Molecular and metabolic mechanisms of cardiac dysfunction in diabetes

CH Mandavia, AR Aroor, VG DeMarco, JR Sowers - Life sciences, 2013 - Elsevier
Diabetes mellitus type 2 (T2DM) is a widespread chronic medical condition with prevalence
bordering on the verge of an epidemic. It is of great concern that cardiovascular disease is …

Molecular dysfunction and phenotypic derangement in diabetic cardiomyopathy

I Evangelista, R Nuti, T Picchioni, F Dotta… - International journal of …, 2019 - mdpi.com
The high incidence and poor prognosis of heart failure (HF) patients affected with diabetes
(DM) is in part related to a specific cardiac remodeling currently recognized as diabetic …

Subcellular remodeling and heart dysfunction in chronic diabetes

NS Dhalla, X Liu, V Panagia… - Cardiovascular research, 1998 - academic.oup.com
Heart dysfunction in chronic diabetes has been observed to be associated with depressed
myofibrillar adenosine triphosphatase activities as well as abnormalities in the sarcoplasmic …

Role of differential signaling pathways and oxidative stress in diabetic cardiomyopathy

K Watanabe, RA Thandavarayan… - Current cardiology …, 2010 - ingentaconnect.com
Diabetes mellitus increases the risk of heart failure independently of underlying coronary
artery disease, and many believe that diabetes leads to cardiomyopathy. The underlying …

Conundrum of pathogenesis of diabetic cardiomyopathy: role of vascular endothelial dysfunction, reactive oxygen species, and mitochondria

M Joshi, SR Kotha, S Malireddy, V Selvaraju… - Molecular and cellular …, 2014 - Springer
Diabetic cardiomyopathy and heart failure have been recognized as the leading causes of
mortality among diabetics. Diabetic cardiomyopathy has been characterized primarily by the …