Junctional adhesion molecule-1 is upregulated in spontaneously hypertensive rats: evidence for a prohypertensive role within the brain stem

H Waki, B Liu, M Miyake, K Katahira, D Murphy… - …, 2007 - Am Heart Assoc
Junctional adhesion molecule-1 (JAM-1) forms part of the tight junction between adjacent
endothelial cells. Using microarray technology, we showed previously that JAM-1 was …

Upregulation of junctional adhesion molecule-A is a putative prognostic marker of hypertension

H Xu, EB Oliveira-Sales, F McBride, B Liu… - Cardiovascular …, 2012 - academic.oup.com
Aims Establishing biochemical markers of pre-hypertension and early hypertension could
help earlier diagnostics and therapeutic intervention. We assess dynamics of junctional …

JAM-A acts via C/EBP-α to promote claudin-5 expression and enhance endothelial barrier function

N Kakogiannos, L Ferrari, C Giampietro… - Circulation …, 2020 - Am Heart Assoc
Rationale: Intercellular tight junctions are crucial for correct regulation of the endothelial
barrier. Their composition and integrity are affected in pathological contexts, such as …

Evidence of specific inflammatory condition in nucleus tractus solitarii of spontaneously hypertensive rats

H Waki, SS Gouraud, M Maeda, JFR Paton - 2010 - Wiley Online Library
Since the nucleus tractus solitarii (NTS) is a pivotal region for regulating the set‐point of
arterial pressure, we proposed a role for it in the development of neurogenic hypertension …

Specific inflammatory condition in nucleus tractus solitarii of the SHR: novel insight for neurogenic hypertension?

H Waki, SS Gouraud, M Maeda, JFR Paton - Autonomic Neuroscience, 2008 - Elsevier
Human essential hypertension is a complex polygenic trait with underlying genetic
components that remain unknown. Since the brainstem structure—the nucleus of the solitary …

[HTML][HTML] Junctional adhesion molecule (JAM)-C deficient C57BL/6 mice develop a severe hydrocephalus

L Wyss, J Schäfer, S Liebner, M Mittelbronn, U Deutsch… - 2012 - journals.plos.org
The junctional adhesion molecule (JAM)-C is a widely expressed adhesion molecule
regulating cell adhesion, cell polarity and inflammation. JAM-C expression and function in …

Down-regulation of chemokine Ccl5 gene expression in the NTS of SHR may be pro-hypertensive

SS Gouraud, H Waki, MER Bhuiyan… - Journal of …, 2011 - journals.lww.com
Objectives Recent studies have demonstrated that pro-inflammatory molecules such as
junctional adhesion molecules-1 are highly expressed in the nucleus tractus solitarii (NTS) …

Is neurogenic hypertension related to vascular inflammation of the brainstem?

JFR Paton, H Waki - Neuroscience & Biobehavioral Reviews, 2009 - Elsevier
Essential hypertension is idiopathic although it is accepted as a complex polygenic trait with
underlying genetic components, which remain unknown. Our supposition is that …

Relocalization of junctional adhesion molecule A during inflammatory stimulation of brain endothelial cells

SM Stamatovic, N Sladojevic, RF Keep… - … and cellular biology, 2012 - Am Soc Microbiol
Junctional adhesion molecule A (JAM-A) is a unique tight junction (TJ) transmembrane
protein that under basal conditions maintains endothelial cell-cell interactions but under …

Downregulation of junctional adhesion molecule-A is involved in the progression of clear cell renal cell carcinoma

P Gutwein, A Schramme, B Voss… - Biochemical and …, 2009 - Elsevier
Junctional adhesion molecule-A (JAM-A) is one component of tight junctions which are
involved in important processes like paracellular permeability, cell polarity, adhesion …