DNA methylation is a mechanism for long-term transcriptional regulation and is required for
normal cellular differentiation. Failure to properly establish or maintain DNA methylation …

DNA methylation pattern mapping is heavily studied in normal and diseased tissues. A
variety of methods have been established to interrogate the cytosine methylation patterns in …

Aberrant DNA methylation is a universal feature of cancer. Here, we present a protocol for
generating high-quality genome-scale DNA methylation sequencing data from a variety of …

Background Growing evidence suggests that DNA methylation plays a role in tissue-specific
differentiation. Current approaches to methylome analysis using enrichment with the methyl …

DNA methylation stabilizes developmentally programmed gene expression states. Aberrant
methylation is associated with disease progression and is a common feature of cancer …

Background DNA methylation has been linked to genome regulation and dysregulation in
health and disease respectively, and methods for characterizing genomic DNA methylation …

Reduced representation bisulfite sequencing (RRBS) is a powerful method of DNA
methylome profiling that can be applied to single cells. However, no previous report has …

DNA methylation is an epigenetic modification that plays an important role in regulating
gene expression and therefore a broad range of biological processes and diseases. DNA …

DNA methylation is an epigenetic modification involved in both normal developmental
processes and disease states through the modulation of gene expression and the …

DNA methylation constitutes an important epigenetic regulation mechanism in many
eukaryotes, although the extent of DNA methylation in the regulation of gene expression in …