Skeletal muscle fibers are formed by the fusion of mononucleated myoblasts into long linear
myotubes, which differentiate and reorganize into multinucleated myofibers that assemble in …

Cell-cell contact inhibition and the mechanical environment of cells have both been shown
to regulate YAP nuclear localization to modulate cell proliferation. Changes in cellular …

Yes-associated protein (YAP) is a key mechanotransduction protein in diverse physiological
and pathological processes; however, a ubiquitous YAP activity regulatory mechanism in …

Mechanical forces transduced to cells through the extracellular matrix are critical regulators
of tissue development, growth, and homeostasis, and can play important roles in directing …

YAP is a key mechanotransduction protein with essential roles in diverse physiological
processes. Dysregulation in YAP activity is associated with multiple diseases such as …

The cardiomyocyte phenotypic switch from a proliferative to terminally differentiated state
results in the loss of regenerative potential of the mammalian heart shortly after birth …

Skeletal muscle is not only translating chemical energy into mechanical work, it is also a
highly adaptive and regenerative tissue whose architecture and functionality is determined …

Actin cytoskeleton dynamics are essential regulatory processes in muscle development,
growth, and regeneration due to their modulation of mechanotransduction, cell proliferation …

Yes‐associated protein (YAP) is a transcriptional coactivator in the Hippo pathway that
regulates cell proliferation, differentiation, and apoptosis. The MEK5/ERK5 MAPK cascade is …

Muscle cell fusion is a multistep process involving cell migration, adhesion, membrane
remodeling and actin-nucleation pathways to generate multinucleated myotubes. However …