Polymorphisms in the inflammatory pathway genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG are …

S Bank, P Skytt Andersen, J Burisch, N Pedersen… - PLoS …, 2014 - journals.plos.org
Background The inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative
colitis (UC), result from the combined effects of susceptibility genes and environmental …

Inflammatory bowel disease: the role of inflammatory cytokine gene polymorphisms

J Balding, WJ Livingstone, J Conroy… - Mediators of …, 2004 - Wiley Online Library
THE mechanisms responsible for development of inflammatory bowel disease (IBD) have
not been fully elucidated, although the main cause of disease pathology is attributed to up …

Association of IL23R, TNFRSF1A, and HLA-DRB1*0103 allele variants with inflammatory bowel disease phenotypes in the Finnish population

M Lappalainen, L Halme, U Turunen… - Inflammatory bowel …, 2008 - academic.oup.com
Background Crohn's disease (CD) and ulcerative colitis (UC), 2 major forms of inflammatory
bowel disease (IBD), are complex disorders with significant genetic predisposition. The first …

Polymorphisms in the toll-like receptor and the IL-23/IL-17 pathways were associated with susceptibility to inflammatory bowel disease in a Danish cohort

S Bank, PS Andersen, J Burisch, N Pedersen, S Roug… - PLoS one, 2015 - journals.plos.org
Background The inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative
colitis (UC), result from the combined effects of susceptibility genes and environmental …

[HTML][HTML] Polymorphisms in NF-κB, PXR, LXR, PPARγ and risk of inflammatory bowel disease

V Andersen, J Christensen, A Ernst… - World journal of …, 2011 - ncbi.nlm.nih.gov
AIM: To investigate the contribution of polymorphisms in nuclear receptors to risk of
inflammatory bowel disease (IBD). METHODS: Genotypes of nuclear factor (NF)-κB (NFKB1) …

Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel …

S Bank, PS Andersen, J Burisch, N Pedersen… - The …, 2014 - nature.com
Antitumor necrosis factor-α (TNF-α) is used for treatment of severe cases of inflammatory
bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). However …

Association between TLR2 and TLR4 gene polymorphisms and the susceptibility to inflammatory bowel disease: a meta-analysis

Y Cheng, Y Zhu, X Huang, W Zhang, Z Han, S Liu - Plos one, 2015 - journals.plos.org
Background The associations between toll-like receptor 2 (TLR2) and toll-like receptor 4
(TLR4) polymorphisms and inflammatory bowel disease (IBD) susceptibility remain …

Immune response and gene polymorphism profiles in Crohn's disease and ulcerative colitis

DMM Queiroz, AG Oliveira, IEB Saraiva… - Inflammatory bowel …, 2009 - academic.oup.com
Background Polymorphisms in genes linked to the innate and adaptive immune response
may be involved in inflammatory bowel disease pathogenesis. Our aim was to investigate …

Investigation of multiple susceptibility loci for inflammatory bowel disease in an Italian cohort of patients

A Latiano, O Palmieri, T Latiano, G Corritore, F Bossa… - PloS one, 2011 - journals.plos.org
Background Recent GWAs and meta-analyses have outlined about 100 susceptibility
genes/loci for inflammatory bowel diseases (IBD). In this study we aimed to investigate the …

Gene polymorphisms of NOD2, IL23R, PTPN2 and ATG16L1 in patients with Crohn's disease: on the way to personalized medicine?

P Hoffmann, D Lamerz, P Hill, M Kirchner, A Gauss - Genes, 2021 - mdpi.com
Genetic and environmental factors are involved in the pathogenesis of inflammatory bowel
diseases (IBD). The study aimed at investigating the potential influence of single nucleotide …