Accurate segregation of genetic information during cell division relies on a multiprotein
complex called the kinetochore, whose formation requires specialized centromeric …

The centromere-specific histone H3 variant CENH3 (also known as CENP-A) is considered
to be an epigenetic mark for establishment and propagation of centromere identity. Pulse …

The centromere is essential for accurate chromosome segregation during mitosis and
meiosis to achieve transmission of genetic information to daughter cells. To facilitate …

Accurate chromosome segregation at mitosis requires the correct assembly of kinetochores,
complexes of centromeric DNA and protein that link chromosomes to spindle microtubules …

Since discovery of the centromere-specific histone H3 variant CENP-A, centromeres have
come to be defined as chromatin structures that establish the assembly site for the complex …

Centromeres play essential roles in equal chromosome segregation by directing the
assembly of the microtubule binding kinetochore and serving as the cohesion site between …

This protocol describes a cell-free system for studying vertebrate centromere and
kinetochore formation. We reconstitute tandem arrays of centromere protein A (CENP-A) …

At each mitosis, accurate segregation of every chromosome is ensured by the assembly of a
kinetochore at each centromeric locus. Six foundation kinetochore proteins that assemble …

The centromere is a specialized region of each chromosome that is essential for faithful
chromosome segregation during mitosis and meiosis in eukaryotic cells. Centromeres are …

During cell division, chromosomes are segregated to nascent daughter cells by attaching to
the microtubules of the mitotic spindle through the kinetochore. Kinetochores are assembled …