Metastatic cancer is a heterogeneous entity, some of which could benefit from local
consolidative radiation therapy (RT). Although randomized evidence is growing in support of …

Metastasis from most adult solid tumors generally has been considered to be widespread
and incurable. Here, I present clinical and molecular data to support the hypothesis that …

Purpose The benefit of local consolidative therapy (LCT) for oligometastasis across
histologies remains uncertain. EXTernal beam radiation to Eliminate Nominal metastatic …

Radiotherapy is a component of the standard of care for many patients with locally advanced
nonmetastatic tumors and increasingly those with oligometastatic tumors. Despite …

Immunotherapy has revolutionized the clinical management of many malignancies but is
infrequently associated with durable objective responses when used as a standalone …

Radiation therapy (RT) is emerging as an interventional modality in the cancer-immunity
cycle, augmenting the activation of an adaptive immune response against tumors. RT …

The treatment paradigm for patients with metastatic cancer has shifted in the era of
oligometastatic disease, 1 novelsystemictherapy, andlocalablativetherapyoptions such as …

Radiotherapy (RT) has been considered a local modality and outcomes have emphasized
local and regional control of tumors. Recent data suggests that RT may activate the immune …

Cancer immunotherapy has transformed traditional treatments, with immune checkpoint
blockade being particularly prominent. However, immunotherapy has minimal benefit for …

The use of local ablative therapy or metastasis-directed therapy is an emerging
management paradigm in oligometastatic and oligoprogressive cancer. Recent randomized …