Developing “osteoimmune-smart” bone substitute materials have become the forefront of
research in bone regeneration. Biocompatible polymer coatings are applied widely to …

The plasma deposited polyoxazoline (PPOx) has been emerging in biomedical applications,
especially for the surface modification of bone tissue engineering scaffold and/or bone …

Abstract Micro/nanostructured TiO2/ZnO coating has been shown to possess multiple
functions, including antibacterial activity and bioactivity. Osteoblast-like SaOS-2 cells were …

As direct effector cells for osteogenesis, osteoblastic cells are commonly used for evaluating
the in vitro osteogenic capacity of bone biomaterials, and the traditional biological principle …

Osteoimmunomodulation has informed the importance of modulating a favorable
osteoimmune environment for successful materials-mediated bone regeneration …

Osteoimmunomodulation is a fascinating approach for balancing osteoimmune through
regulating reciprocal interactions between bone cells and immune cells [1]. Implantation of …

The control of early inflammatory reactions and recruitment of progenitor cells are critical for
subsequent tissue repair and regeneration after biomaterial implantation. The aim of this …

As bone biology develops, it is gradually recognized that bone regeneration is a
pathophysiological process that requires the simultaneous participation of multiple systems …

Macrophages play a very fundamental role in bone regeneration. Changing the
physicochemical properties of biomaterials to regulate the genes and protein expressions of …

Those who have used traditional biomaterials as bone substitutes have always regarded the
immune response as an obstacle leading to implant failure. However, cumulative evidence …