High-throughput amplicon sequencing has become a well-established approach for
microbial community profiling. Correlating shifts in the relative abundances of bacterial taxa …

One of the major methods to identify microbial community composition, to unravel microbial
population dynamics, and to explore microbial diversity in environmental samples is high …

Background: Data from 16S amplicon sequencing present challenges to ecological and
statistical interpretation. In particular, library sizes often vary over several ranges of …

Measuring the microbial diversity in natural and engineered environments is important for
ecosystem characterization, ecosystem monitoring and hypothesis testing. Although the …

Marker gene amplicon sequencing is often preferred over whole genome sequencing for
microbial community characterization, due to its lower cost while still enabling assessment of …

Metagenomic sequencing has enabled detailed investigation of diverse microbial
communities, but understanding their spatiotemporal variability remains an important …

Background Recent advances in sequencing technologies and bioinformatics tools have
allowed for large-scale microbiome studies that are rapidly advancing medical research …

Microbial ecology as a scientific field is fundamentally driven by technological advance. The
past decade's revolution in DNA sequencing cost and throughput has made it possible for …

The quantification of relative and absolute taxa-specific abundances in complex microbial
communities is crucial for understanding and modeling natural and engineered ecosystems …

Identifying differentially abundant microbes is a common goal of microbiome studies.
Multiple methods are used interchangeably for this purpose in the literature. Yet, there are …