The pancreatic islets of Langerhans are responsible for the regulated release of the
endocrine hormones insulin and glucagon that participate in the control of glucose …

Under physiological conditions, insulin secretion from pancreatic β-cells is tightly regulated
by different factors, including nutrients, nervous system, and other hormones. Pancreatic β …

Adenosine is known to influence different kinds of cells, including β-cells of the pancreas.
However, the role of this nucleoside in the regulation of insulin secretion is not fully …

Glucose metabolism by pancreatic β and α cells is essential for stimulation of insulin
secretion and inhibition of glucagon secretion. Studies using rodent islets have suggested …

Adenine nucleotides are thought to serve as second messengers in the control of beta-cell
function by glucose, eg by regulating the activity of ATP-dependent K+ channels. However …

Adenosine uptake (consisting of both membrane transport and subsequent metabolism) was
studied in mouse pancreatic islets in order to further evaluate the ability of adenosine to …

Changes in the ATP: ADP ratio in pancreatic B cells may participate in the regulation of
insulin secretion by glucose. Here, we have investigated the possible role of guanine …

Previous studies have shown that adenosine, by activation of purinergic A2-receptors,
stimulates glucagon secretion and increases vascular flow rate in isolated perfused …

Mouse islets were used to study the effects of adenosine and its stable analogue L-N6-
phenylisopropyladenosine (L-PIA) on pancreatic beta-cell function. At a high concentration …

Extracellular adenosine triphosphate (ATP) has distinct effects on insulin secretion from
pancreatic β-cells between rats and mice. Using a confocal microscope, we compared …