High-throughput sequencing technologies are a milestone in molecular biology for
facilitating great advances in genomics by enabling the deposit of large volumes of …

Pan-genome analysis enables an assessment of the total gene content from a set of
genome sequences. Since the 'first'defined pan-genome (Tettelin et al., 2005), many tools …

Pangenome analysis is an indispensable step in bacterial genomics to address the high
variability of bacteria genomes. However, speed and scalability remain a challenge for …

Motivation Next-generation sequencing technology is generating a wealth of highly similar
genome sequences for many species, paving the way for a transition from single-genome to …

With increased production of genomic data since the advent of next-generation sequencing
(NGS), there has been a need to develop new bioinformatics tools and areas, such as …

Background Massively parallel DNA sequencing instruments are enabling the decoding of
whole genomes at significantly lower cost and higher throughput than classical Sanger …

Next-generation sequencing methods provide comprehensive data for the analysis of
structural and functional analysis of the genome. The draft genomes with low contig number …

Long reads obtained from third-generation sequencing platforms can help overcome the
long-standing challenge of the de novo assembly of sequences for the genomic analysis of …

Background Comparative analysis of whole genome sequence data from closely related
prokaryotic species or strains is becoming an increasingly important and accessible …

The human reference genome is still incomplete, especially for those population-specific or
individual-specific regions, which may have important functions. Here, we developed a …