Critical illness in COVID-19 is caused by inflammatory lung injury, mediated by the host
immune system. We and others have shown that host genetic variation influences the …

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic
variation influences the development of illness requiring critical care or hospitalization,–after …

Pulmonary inflammation drives critical illness in Covid-19,; creating a clinically
homogeneous extreme phenotype, which we have previously shown to be highly efficient for …

Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype
that we have previously shown to be highly efficient for discovery of genetic associations …

Host-mediated lung inflammation is present, and drives mortality, in the critical illness
caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with …

Studies of genetic factors associated with severe COVID-19 in young adults have been
limited in non-Caucasian populations. Here, we use whole exome sequencing to …

Despite rapid progress in characterizing the role of host genetics in SARS-Cov-2 infection,
there is limited understanding of genes and pathways that contribute to COVID-19. Here, we …

Studies of genetic factors associated with severe COVID-19 in young adults have been
limited in non-Caucasian populations. Here, we clinically characterize a case series of …

This study compared whole genome sequences from over 7,000 patients critically ill with
COVID-19 with the genomes of more than 48,000 matched controls (that is, similar …

Objective: Interindividual variability in the clinical progression of COVID-19 may be
explained by host genetics. Emerging literature supports a potential inherited predisposition …