Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance
PJ Enriori, P Sinnayah, SE Simonds… - Journal of …, 2011 - Soc Neuroscience
Leptin regulates body weight in mice by decreasing appetite and increasing sympathetic
nerve activity (SNA), which increases energy expenditure in interscapular brown adipose …
nerve activity (SNA), which increases energy expenditure in interscapular brown adipose …
[HTML][HTML] Leptin increases sympathetic nerve activity via induction of its own receptor in the paraventricular nucleus
Z Shi, NE Pelletier, J Wong, B Li, AD Sdrulla… - Elife, 2020 - elifesciences.org
Whether leptin acts in the paraventricular nucleus (PVN) to increase sympathetic nerve
activity (SNA) is unclear, since PVN leptin receptors (LepR) are sparse. We show in rats that …
activity (SNA) is unclear, since PVN leptin receptors (LepR) are sparse. We show in rats that …
Hypothalamic arcuate nucleus mediates the sympathetic and arterial pressure responses to leptin
K Rahmouni, DA Morgan - Hypertension, 2007 - Am Heart Assoc
Leptin is an adipocyte-derived hormone that plays an important role in the regulation of
energy homeostasis through its action in the central nervous system. Leptin decreases body …
energy homeostasis through its action in the central nervous system. Leptin decreases body …
Brain stem is a direct target for leptin's action in the central nervous system
T Hosoi, T Kawagishi, Y Okuma, J Tanaka… - …, 2002 - academic.oup.com
Leptin is a circulating molecule for the regulation of food intake and body weight suggested
to be mediated in the hypothalamus via Ob-Rb receptor, which activates Janus kinase …
to be mediated in the hypothalamus via Ob-Rb receptor, which activates Janus kinase …
[HTML][HTML] Leptin regulation of neuroendocrine systems
The discovery of leptin has enhanced understanding of the interrelationship between
adipose energy stores and neuronal circuits in the brain involved in energy balance and …
adipose energy stores and neuronal circuits in the brain involved in energy balance and …
Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity
C Koch, RA Augustine, J Steger… - Journal of …, 2010 - Soc Neuroscience
Obesity is associated with resistance to the actions of both leptin and insulin via
mechanisms that remain incompletely understood. To investigate whether leptin resistance …
mechanisms that remain incompletely understood. To investigate whether leptin resistance …
Leptin activates neurons in ventrobasal hypothalamus and brainstem
Leptin is a circulating protein secreted by adipocytes which has profound feeding, metabolic,
and neuroendocrine effects. Leptin receptors have been localized to the hypothalamus, but …
and neuroendocrine effects. Leptin receptors have been localized to the hypothalamus, but …
In vivo effects of leptin on autonomic nerve activity and lipolysis in rats
J Shen, M Tanida, A Niijima, K Nagai - Neuroscience letters, 2007 - Elsevier
Leptin, a 16-kDa protein, is produced by white adipose tissue (WAT), and is thought to serve
as a feedback signal indicating the size of fat stores. Considerable amount of data have …
as a feedback signal indicating the size of fat stores. Considerable amount of data have …
The role of leptin in the regulation of energy balance and adiposity
G Van Dijk - Journal of neuroendocrinology, 2001 - Wiley Online Library
Since its discovery, leptin (a 167‐amino acid product of the OB gene) has quickly moved to
the forefront as an important hormone for regulation of energy balance. It closes a feedback …
the forefront as an important hormone for regulation of energy balance. It closes a feedback …
Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin
JK Elmquist - Physiology & behavior, 2001 - Elsevier
Leptin affects feeding, metabolism, and neuroendocrine status. It is now clearly established
that the hypothalamus coordinates these responses, though the specific brain regions …
that the hypothalamus coordinates these responses, though the specific brain regions …