Leptin regulates body weight in mice by decreasing appetite and increasing sympathetic
nerve activity (SNA), which increases energy expenditure in interscapular brown adipose …

Whether leptin acts in the paraventricular nucleus (PVN) to increase sympathetic nerve
activity (SNA) is unclear, since PVN leptin receptors (LepR) are sparse. We show in rats that …

Leptin is an adipocyte-derived hormone that plays an important role in the regulation of
energy homeostasis through its action in the central nervous system. Leptin decreases body …

Leptin is a circulating molecule for the regulation of food intake and body weight suggested
to be mediated in the hypothalamus via Ob-Rb receptor, which activates Janus kinase …

The discovery of leptin has enhanced understanding of the interrelationship between
adipose energy stores and neuronal circuits in the brain involved in energy balance and …

Obesity is associated with resistance to the actions of both leptin and insulin via
mechanisms that remain incompletely understood. To investigate whether leptin resistance …

Leptin is a circulating protein secreted by adipocytes which has profound feeding, metabolic,
and neuroendocrine effects. Leptin receptors have been localized to the hypothalamus, but …

Leptin, a 16-kDa protein, is produced by white adipose tissue (WAT), and is thought to serve
as a feedback signal indicating the size of fat stores. Considerable amount of data have …

Since its discovery, leptin (a 167‐amino acid product of the OB gene) has quickly moved to
the forefront as an important hormone for regulation of energy balance. It closes a feedback …

Leptin affects feeding, metabolism, and neuroendocrine status. It is now clearly established
that the hypothalamus coordinates these responses, though the specific brain regions …