Effect of epidermal growth factor-like peptides on the metabolism of in vitro-matured mouse oocytes and cumulus cells

D Richani, ML Sutton-McDowall, LA Frank… - Biology of …, 2014 - academic.oup.com
Oocyte in vitro maturation (IVM) is an assisted reproductive technology that involves the
maturation of cumulus-oocyte complexes (COCs) that are then capable of normal …

Mode of oocyte maturation affects EGF-like peptide function and oocyte competence

D Richani, LJ Ritter, JG Thompson… - MHR: Basic science of …, 2013 - academic.oup.com
The function and impact of epidermal growth factor (EGF)-like peptide signalling during
ovulation and in vivo oocyte maturation (IVV) has been recently characterized, however, little …

Role for cumulus cell-produced EGF-like ligands during primate oocyte maturation in vitro

JK Nyholt de Prada, YS Lee… - American Journal …, 2009 - journals.physiology.org
The developmental competence of in vitro-matured (IVM) rhesus macaque cumulus oocyte
complexes (COCs) is deficient compared with in vivo-matured (IVM) oocytes. To improve …

Pre‐maturation with cAMP modulators in conjunction with EGF‐like peptides during in vitro maturation enhances mouse oocyte developmental competence

D Richani, X Wang, HT Zeng, J Smitz… - Molecular …, 2014 - Wiley Online Library
Recent studies have independently shown that cyclic adenosine 3′ 5′‐monophosphate
(cAMP) modulation prior to in vitro maturation (IVM) and epidermal growth factor (EGF)‐like …

Epiregulin can effectively mature isolated cumulus–oocyte complexes, but fails as a substitute for the hCG/epidermal growth factor stimulus on cultured follicles

S Romero, J Smitz - Reproduction, 2009 - rep.bioscientifica.com
Epiregulin mediates LH ovulatory effects in vitro. This study evaluated the use of epiregulin
as an alternative to hCG/epidermal growth factor (EGF) stimulus upon cultured ovarian …

EGF‐like peptides mediate FSH‐induced maturation of cumulus cell‐enclosed mouse oocytes

SM Downs, J Chen - Molecular Reproduction and …, 2008 - Wiley Online Library
This study was carried out to examine the participation of epidermal growth factor (EGF)‐like
peptides in the induction of germinal vesicle breakdown (GVB) in mouse cumulus cell …

Direct positive effect of epidermal growth factor on the cytoplasmic maturation of mouse and human oocytes

K Das, LE Stout, HC Hensleigh, GE Tagatz… - Fertility and sterility, 1991 - Elsevier
Objective Immature mammalian oocytes cultured in vitro undergo inadequate cytoplasmic
maturation and hence have a limited potential for fertilization. Our primary objective was to …

In vitro maturation of human germinal vesicle-stage oocytes: role of epidermal growth factor-like growth factors in the culture medium

I Ben-Ami, A Komsky, O Bern, E Kasterstein… - Human …, 2011 - academic.oup.com
BACKGROUND In vitro maturation (IVM) of oocytes is a promising technique to reduce the
costs and avert the side effects of gonadotrophin stimulation for IVF. The pregnancy rates …

Epidermal growth factor enhances preimplantation developmental competence of maturing mouse oocytes

R De La Fuente, MJ O'Brien, JJ Eppig - Human Reproduction, 1999 - academic.oup.com
The objective of this study was to determine whether epidermal growth factor (EGF)
promotes nuclear and cytoplasmic maturation of mouse oocytes grown in vivo or in vitro. In …

Epidermal growth factor in human follicular fluid stimulates mouse oocyte maturation in vitro

K Das, WR Phipps, HC Hensleigh, GE Tagatz - Fertility and sterility, 1992 - Elsevier
Objective To study the effect of human follicular fluid (FF) and the specific contribution of its
epidermal growth factor (EGF) component on the in vitro maturation of cumulus-enclosed …