Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation
of inflammatory responses and thus have important roles in the pathogenesis of …

Although peripheral blood eosinophilia is strongly associated with the risk of developing
asthma, genetic determinants of eosinophilia have not been extensively studied. We used …

Immunoglobulin E (IgE) is a central mediator of allergic (atopic) inflammation. Therapies
directed against IgE can alleviate hay fever and allergic asthma,. Genetic association …

We examined common variation in asthma risk by conducting a meta-analysis of worldwide
asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of …

Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder associated with allergic
hypersensitivity to food. We interrogated> 1.5 million genetic variants in EoE cases of …

Asthma, hay fever (or allergic rhinitis) and eczema (or atopic dermatitis) often coexist in the
same individuals, partly because of a shared genetic origin,,. To identify shared risk variants …

Asthma is a chronic and genetically complex respiratory disease that affects over 300 million
people worldwide. Here, we report a genome-wide analysis for asthma using data from the …

Several genome‐wide screens for asthma and related phenotypes have been published to
date but data on fine‐mapping are scarce. For higher resolution we performed a fine …

Eosinophils are multifunctional, evolutionary conserved leukocytes that are involved in a
plethora of responses ranging from regulation of tissue homeostasis to host defense and …

Background IL‐10 has several functional effects relevant to asthma. It can modulate IgE
production and induce apoptosis in eosinophils. Polymorphisms of IL‐10 gene have been …