Antibody-mediated glomerulonephritis (AGN) is a clinical manifestation of many
autoimmune kidney diseases for which few effective treatments exist. Chronic inflammatory …

Immune-mediated kidney diseases are a leading cause of end-stage renal disease. Despite
recent discoveries, the immunopathogenesis of this heterogeneous disease group remains …

In recent years, proinflammatory cytokines in the nephritic kidney appear to contribute to the
pathogenesis of AGN. The complex inflammatory cytokine network that drives renal …

Immune-mediated glomerular diseases (glomerulonephritis) encompass a heterogeneous
collection of diseases that cause inflammation within the glomerulus and other renal …

The IL-17 cytokine family and the cognate receptors thereof have a unique role in organ-
specific autoimmunity. Most studies have focused on the founding member of the IL-17 …

In anti-glomerular basement membrane glomerulonephritis (anti-GBM GN), antibodies and T
cells directed against the Goodpasture antigen, the non-collagenous domain of the α3-chain …

T helper 17 (Th17) lymphocytes promote renal inflammation in anti-glomerular basement
membrane glomerulonephritis (anti-GBM GN), and signal transducer and activator of …

Crescentic glomerulonephritis (cGN) is a severe clinical manifestation in a subset of patients
with Systemic lupus erythematosus. Lack of understanding of the pathogenesis of cGN act …

Background IL-17A–producing CD4+ T helper (TH 17) cells play a critical role in
autoimmune and chronic inflammatory diseases, such as crescentic GN. The …

The TH 17 immune response has a central role in the pathogenesis of autoimmune
diseases, implicating the TH 17 master cytokine, IL-17A, as the critical mediator of diseases …